S
Sarah Warren
Researcher at NanoString Technologies
Publications - 99
Citations - 8232
Sarah Warren is an academic researcher from NanoString Technologies. The author has contributed to research in topics: Immune system & Immunotherapy. The author has an hindex of 24, co-authored 78 publications receiving 3598 citations.
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Journal ArticleDOI
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink,Sangeetha M. Reddy,Jianjun Gao,Shaojun Zhang,Rafet Basar,Rohit Thakur,Keren Yizhak,Moshe Sade-Feldman,Moshe Sade-Feldman,Jorge Blando,Guangchun Han,Vancheswaran Gopalakrishnan,Yuanxin Xi,Hao Zhao,Rodabe N. Amaria,Hussein Abdul-Hassan Tawbi,Alex P. Cogdill,Wenbin Liu,Valerie S. LeBleu,Fernanda G. Kugeratski,Sapna Pradyuman Patel,Michael A. Davies,Patrick Hwu,Jeffrey E. Lee,Jeffrey E. Gershenwald,Anthony Lucci,Reetakshi Arora,Scott E. Woodman,Emily Z. Keung,Pierre Olivier Gaudreau,Alexandre Reuben,Christine N. Spencer,Elizabeth M. Burton,Lauren E. Haydu,Alexander J. Lazar,Roberta Zapassodi,Courtney W. Hudgens,Deborah A. Ledesma,SuFey Ong,Michael Bailey,Sarah Warren,Disha Rao,Oscar Krijgsman,Elisa A. Rozeman,Daniel S. Peeper,Christian U. Blank,Ton N. Schumacher,Lisa H. Butterfield,Monika A. Zelazowska,Kevin M. McBride,Raghu Kalluri,James P. Allison,Florent Petitprez,Florent Petitprez,Wolf H. Fridman,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Nir Hacohen,Nir Hacohen,Katayoun Rezvani,Padmanee Sharma,Michael T. Tetzlaff,Linghua Wang,Jennifer A. Wargo +64 more
TL;DR: B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.
Journal ArticleDOI
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
Rita Cabrita,Martin Lauss,Adriana Sanna,Marco Donia,Mathilde Skaarup Larsen,Shamik Mitra,Iva Johansson,Bengt Phung,Katja Harbst,Johan Vallon-Christersson,Alison van Schoiack,Kristina Lövgren,Sarah Warren,Karin Jirström,Håkan Olsson,Kristian Pietras,Christian Ingvar,Karolin Isaksson,Dirk Schadendorf,Henrik Schmidt,Lars Bastholt,Ana Carneiro,Jennifer A. Wargo,Inge Marie Svane,Göran Jönsson +24 more
TL;DR: It is found that the co-occurrence of tumour-associated CD8 + T cells and CD20 + B cells, and the formation of tertiary lymphoid structures, are linked with improved survival in cohorts of patients with metastatic melanoma.
Journal ArticleDOI
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Lorenzo Galluzzi,Ilio Vitale,Sarah Warren,Sandy Adjemian,Patrizia Agostinis,Aitziber Burque Martinez,Timothy A. Chan,George Coukos,Sandra Demaria,Eric Deutsch,Dobrin Draganov,Richard L. Edelson,Silvia C. Formenti,Jitka Fucikova,Lucia Gabriele,Udo S. Gaipl,Sofia R. Gameiro,Abhishek D. Garg,Encouse B. Golden,Jian Han,Kevin J. Harrington,Kevin J. Harrington,Akseli Hemminki,James W. Hodge,Dewan Md Sakib Hossain,Timothy M Illidge,Michael Karin,Howard L. Kaufman,Oliver Kepp,Guido Kroemer,Juan José Lasarte,Sherene Loi,Michael T. Lotze,Gwenola Manic,Taha Merghoub,Taha Merghoub,Alan Melcher,Karen L. Mossman,Felipe Prosper,Øystein Rekdal,Maria Rescigno,Chiara Riganti,Antonella Sistigu,Mark J. Smyth,Radek Spisek,John Stagg,Bryan E. Strauss,Daolin Tang,Kazuki Tatsuno,Stefaan Van Gool,Peter Vandenabeele,Takahiro Yamazaki,Dmitriy Zamarin,Dmitriy Zamarin,Laurence Zitvogel,Alessandra Cesano,Francesco M. Marincola +56 more
TL;DR: An updated operational definition of immunogenic cell death is provided, the key factors that dictate the ability of dying cells to drive an adaptive immune response are discussed, and experimental assays that are currently available for the assessment of ICD in vitro and in vivo are summarized.
Journal ArticleDOI
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Christopher Garris,Sean P. Arlauckas,Rainer H. Kohler,Marcel P. Trefny,Seth B. Garren,Cecile Piot,Camilla Engblom,Christina Pfirschke,Marie Siwicki,Jeremy Gungabeesoon,Gordon J. Freeman,Sarah Warren,SuFey Ong,Erica Browning,Christopher G. Twitty,Robert H. Pierce,Mai H. Le,Alain Algazi,Adil Daud,Sara I. Pai,Alfred Zippelius,Ralph Weissleder,Mikael J. Pittet +22 more
TL;DR: It is found that activating the non‐canonical NF‐&kgr;B transcription factor pathway amplified IL‐12‐producing DCs and sensitized tumors to anti‐PD‐1 treatment, suggesting a therapeutic strategy to improve responses to checkpoint blockade.
Journal ArticleDOI
Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma
Christian U. Blank,Elisa A. Rozeman,Lorenzo F. Fanchi,Karolina Sikorska,Bart A. van de Wiel,Pia Kvistborg,Oscar Krijgsman,Marlous van den Braber,Daisy Philips,Annegien Broeks,Johannes V. Van Thienen,H. Mallo,Sandra Adriaansz,Sylvia ter Meulen,Loes M. Pronk,Lindsay G Grijpink-Ongering,Annemarie Bruining,Rachel M. Gittelman,Sarah Warren,Harm van Tinteren,Daniel S. Peeper,John B. A. G. Haanen,Alexander C.J. van Akkooi,Ton N. Schumacher +23 more
TL;DR: It is found that neoadjuvant ipilimumab + nivolumab expand more tumor-resident T cell clones than adjuvant application, and warrants future evaluation with modified dosing schedules to reduce treatment-related adverse events.