K
Karolin V. Dorn
Researcher at Stanford University
Publications - 3
Citations - 677
Karolin V. Dorn is an academic researcher from Stanford University. The author has contributed to research in topics: Cilium & Hedgehog. The author has an hindex of 3, co-authored 3 publications receiving 611 citations.
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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
TL;DR: It is proposed that the Sufu-Gli3 interaction is a major control point in the Hedgehog pathway, a pathway that plays important roles in both development and cancer.
Journal ArticleDOI
A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
TL;DR: The data suggest that the Smo-Evc2 signaling complex at the EvC zone is required for Hh signal transmission and elucidate the molecular basis of two human ciliopathies.
Journal ArticleDOI
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
Ganesh V. Pusapati,Casey E. Hughes,Karolin V. Dorn,Dapeng Zhang,Priscilla Sugianto,L. Aravind,Rajat Rohatgi +6 more
TL;DR: A complex between two ciliary proteins, EFCAB7 and IQCE, which positively regulates the Hh pathway, and suggests that emergence of these complexes might have been important for adaptation of an ancient organelle, the cilium, for an animal-specific signaling network.