K
Kartik Balachandran
Researcher at University of Arkansas
Publications - 49
Citations - 2050
Kartik Balachandran is an academic researcher from University of Arkansas. The author has contributed to research in topics: Aortic valve & Traumatic brain injury. The author has an hindex of 19, co-authored 47 publications receiving 1813 citations. Previous affiliations of Kartik Balachandran include University of Arkansas at Little Rock & Wyss Institute for Biologically Inspired Engineering.
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Journal ArticleDOI
Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway
TL;DR: The results demonstrate that altered hemodynamics stimulates the expression of AV leaflet endothelial adhesion molecules in a TGF-&bgr;1– and BMP-4–dependent manner, providing some potential directions for future drug-based therapies for AV diseases.
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Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.
TL;DR: Elevated mechanical stretch on aortic valve cusps may detrimentally alter the proteolytic enzyme expression and activity in valve cells, which may trigger a cascade of events leading to an accelerated valve degeneration and disease progression.
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Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification
TL;DR: Recent efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification are reviewed.
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Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve
Kartik Balachandran,Patrick W. Alford,Jill Wylie-Sears,Josue A. Goss,Anna Grosberg,Joyce Bischoff,Elena Aikawa,Robert A. Levine,Kevin Kit Parker +8 more
TL;DR: Results suggest that cyclic mechanical strain regulates EMT in a strain magnitude and directionally dependent manner, which implies that the functional properties of the valve are sensitive to EMT.
Journal ArticleDOI
An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch.
Kartik Balachandran,Suchitra Konduri,Philippe Sucosky,Hanjoong Jo,Hanjoong Jo,Ajit P. Yoganathan +5 more
TL;DR: Results show that circumferential cyclic stretch is a possible mediator for AVL remodeling activity and that the contractile and fibrotic phenotypic expression of valve interstitial cells was enhanced.