K
Kate Fynes
Researcher at University College London
Publications - 5
Citations - 577
Kate Fynes is an academic researcher from University College London. The author has contributed to research in topics: Retinal pigment epithelium & Induced pluripotent stem cell. The author has an hindex of 5, co-authored 5 publications receiving 400 citations. Previous affiliations of Kate Fynes include University of London & UCL Institute of Ophthalmology.
Papers
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Journal ArticleDOI
Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.
Lyndon da Cruz,Kate Fynes,Odysseas Georgiadis,Odysseas Georgiadis,Odysseas Georgiadis,Julie Kerby,Yvonne Hsu-Lin Luo,Yvonne Hsu-Lin Luo,Yvonne Hsu-Lin Luo,Ahmad Ahmado,Amanda J. Vernon,Julie T. Daniels,Britta Nommiste,Shazeen M Hasan,Sakina B Gooljar,Amanda-Jayne F. Carr,Anthony A. Vugler,Conor M. Ramsden,Conor M. Ramsden,Magda Bictash,Mike Fenster,Juliette Steer,Tricia Harbinson,Anna Wilbrey,Adnan Tufail,Adnan Tufail,Gang Feng,Mark Whitlock,Anthony G. Robson,Anthony G. Robson,Graham E. Holder,Graham E. Holder,Mandeep S. Sagoo,Mandeep S. Sagoo,Peter T. Loudon,Paul J. Whiting,Paul J. Whiting,Peter J. Coffey,Peter J. Coffey,Peter J. Coffey +39 more
TL;DR: This work supports the feasibility and safety of hESC-RPE patch transplantation as a regenerative strategy for AMD and presents the preclinical surgical, cell safety and tumorigenicity studies leading to trial approval.
Journal ArticleDOI
Engineering Efficient Retinal Pigment Epithelium Differentiation From Human Pluripotent Stem Cells
Amelia Lane,Lissa Rachel Philip,Ludmila Ruban,Kate Fynes,Matthew Smart,Amanda Carr,Chris Mason,Peter J. Coffey +7 more
TL;DR: By monitoring the emergence of pigmented cells over time, it is shown how the cell line, passaging method, passage number, and seeding density have a significant and reproducible effect on the RPE yield.
Journal ArticleDOI
Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC).
David A. Carter,Matthew Smart,William V. G. Letton,Conor M. Ramsden,Conor M. Ramsden,Britta Nommiste,Li Li Chen,Kate Fynes,Manickam N. Muthiah,Pollyanna Goh,Amelia Lane,Michael B. Powner,Andrew R. Webster,Andrew R. Webster,Lyndon da Cruz,Lyndon da Cruz,Anthony T. Moore,Anthony T. Moore,Anthony T. Moore,Peter J. Coffey,Amanda-Jayne F. Carr +20 more
TL;DR: It is shown that BEST1 is expressed more abundantly in peripheral RPE compared to central RPE and is also expressed in cells of the developing retina during human eye development, suggesting that higher levels of mislocalised BEST1 expression in the periphery could provide a mechanism that leads to the distinct clinical phenotype observed in ADVIRC patients.
Book ChapterDOI
Stem cell-derived retinal pigment epithelium transplantation for treatment of retinal disease.
Britta Nommiste,Kate Fynes,Victoria E. Tovell,Conor M. Ramsden,Conor M. Ramsden,Lyndon Da Cruz,Lyndon Da Cruz,Peter J. Coffey,Peter J. Coffey,Peter J. Coffey +9 more
TL;DR: This chapter examines some of these initial proof-of-principle studies for the replacement of RPE cells in age-related macular degeneration (AMD) patients, and goes on to review the use of pluripotent stem cells as a source for RPE replacement in a number of current AMD clinical trials.
Journal ArticleDOI
The differential effects of 2% oxygen preconditioning on the subsequent differentiation of mouse and human pluripotent stem cells
TL;DR: The impact of low oxygen preconditioning was to prime human cells for ectodermal lineage commitment during subsequent EB differentiation, with significant upregulation of Nestin and β3-tubulin.