P
Paul J. Whiting
Researcher at Pfizer
Publications - 178
Citations - 22171
Paul J. Whiting is an academic researcher from Pfizer. The author has contributed to research in topics: Receptor & GABAA receptor. The author has an hindex of 78, co-authored 174 publications receiving 21463 citations. Previous affiliations of Paul J. Whiting include Merck & Co. & UCL Institute of Neurology.
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Journal ArticleDOI
Which GABAA-receptor subtypes really occur in the brain?
Ruth M. McKernan,Paul J. Whiting +1 more
TL;DR: It is concluded that the number of major subtypes is probably less than ten but their physiological roles have yet to be clearly defined and this represents the next step in GABAA-receptor research.
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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Ruth M. McKernan,Thomas W. Rosahl,David S. Reynolds,Cyrille Sur,Keith A. Wafford,John R. Atack,Sophie J. Farrar,J Myers,G.P. Cook,Pushpinder Ferris,L Garrett,Linda J. Bristow,George R. Marshall,Alison J. Macaulay,N. Brown,Owain W. Howell,Kevin W. Moore,Robert W. Carling,Leslie J. Street,Castro Jl,C.I. Ragan,G. R. Dawson,Paul J. Whiting +22 more
TL;DR: This work created genetically modified mice with a diazepam-insensitive α1 subtype and a selective BZ site ligand to explore GABAA receptor subtypes mediating specific physiological effects and revealed that the α1Subtype mediated the sedative, but not the anxiolytic effects of benzodiazepines.
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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
J. Kirsty Millar,Benjamin S. Pickard,Shaun Mackie,Rachel James,Sheila Christie,Sebastienne R. Buchanan,M. Pat Malloy,Jennifer E. Chubb,Elaine Huston,George S. Baillie,Pippa A. Thomson,Elaine V. Hill,Nicholas J. Brandon,Jean-Christophe Rain,L. Miguel Camargo,Paul J. Whiting,Miles D. Houslay,Douglas Blackwood,Douglas Blackwood,Walter J. Muir,Walter J. Muir,David J. Porteous +21 more
TL;DR: The disrupted in schizophrenia 1 (DISC1) gene is disrupted by a balanced translocation in a subject diagnosed with schizophrenia and a relative with chronic psychiatric illness and a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP is proposed.
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Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor
Neil Collinson,Frederick M. Kuenzi,Wolfgang Jarolimek,Karen A. Maubach,Rosa Cothliff,Cyrille Sur,Alison J. Smith,Franklin Otu,Owain W. Howell,John R. Atack,Ruth M. McKernan,Guy R. Seabrook,G. R. Dawson,Paul J. Whiting,Thomas W. Rosahl +14 more
TL;DR: Data suggest that α5-containing GABAA receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus.
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Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
TL;DR: The pharmacology of the stable cell line expressing human alpha(4)beta(3)delta GABA(A) receptor was investigated using whole-cell patch-clamp techniques as discussed by the authors.