Anna Wilbrey

TL;DR: This work supports the feasibility and safety of hESC-RPE patch transplantation as a regenerative strategy for AMD and presents the preclinical surgical, cell safety and tumorigenicity studies leading to trial approval.

TL;DR: Seven subtypes of colonic sensory neurons are identified using unbiased single-cell RNA-sequencing and translation of patterning to protein expression is confirmed, describing sensory diversity encompassing all modalities of Colonic neuronal sensitivity.

TL;DR: It is estimated that recall-by-genotype studies that use iPSC-derived cells will require cells from at least 20–80 individuals to detect the effects of regulatory variants with moderately large effect sizes, despite high differentiation-induced variability.

TL;DR: It is reported that Nav1.7 is the predominant functional TTX-sensitive Nav in mouse and human nociceptors and contributes to the initiation and the upstroke phase of the nOCiceptor action potential, and a role for Nav 1.7 in influencing synaptic transmission in the dorsal horn of the spinal cord as well as peripheral neuropeptide release in the skin is confirmed.

TL;DR: This work describes the evolution of cell populations over 6 weeks of directed differentiation; a process that results in the generation of a largely homogeneous population of neurons that are both molecularly and functionally comparable to human sensory neurons derived from mature dorsal root ganglia.