Kate L. Liebmann

TL;DR: Two-step route to a broad range of 6'-substituted luciferin analogues was developed to enable more extensive study of the 6'-functionality and revealed thioether inhibitors and unexpectedly luminogenic aryl amine derivatives.

TL;DR: Feeding rapamycin delayed the onset of a molt and resulted in abnormally larger larvae, indicating that TOR signaling also plays a role in systemic growth and couples the nutritional status of the larva to the endocrine system to regulate the timing of amolt.

TL;DR: Many fluorophores, and all bright light-emitting substrates for firefly luciferase, contain hydroxyl or amine electron donors, and sulfonamides were found to be capable of serving as replacements for these canonical groups.

TL;DR: Data reveal a new regulator of one of the most studied signal transduction pathways in metazoans and provides a novel, completely untapped therapeutic target for silencing the aberrant ß-catenin signaling that drives hyperproliferation in many cancers.

TL;DR: A panel of three insect ACSLs with a palette of >20 luciferin analogues is profiled, finding that an ACSL from the fruit fly Drosophila melanogaster is a latent luciferase that will emit light with the synthetic Luciferin CycLuc2, and an AC SL from the luminescent beetle Pyrophorus angustus lacks luciferases activity with all tested analogues.