Showing papers by "Katharina Wimmer published in 1998"
TL;DR: Using RT-PCR, this work demonstrates widespread expression of both Evi1 forms in the adult mouse, as well as their upregulation during in vitro hematopoietic differentiation, underscore the biological importance of both EVI1 and MDS1-EVI1.
21 citations
01 Jan 1998
TL;DR: Using a novel two-dimensional genome scanning approach to detect gene dosage alterations in tumors, loci that exhibited hypermethylation and others that exhibited hypomethylation in lung adenocarcinoma are identified and some of the methylation changes observed are unlikely to be due to methylation errors.
Abstract: Recent evidence has suggested a role for DNA methylation changes and for DNA (cytosine 5-) methyltransferase in some aspect of tumor development Limited data are currently available related to changes in the methylation process in lung cancer Using a novel two-dimensional genome scanning approach to detect gene dosage alterations in tumors, we have identified loci that exhibited hypermethylation and others that exhibited hypomethylation in lung adenocarcinoma The data suggest that some of the methylation changes observed are unlikely to be due to methylation errors Full implementation of the genome scanning approach will probably uncover a large number of loci affected by methylation change in lung carcinogenesis
4 citations