Katherine S. Lovejoy

TL;DR: The results indicate that OCT1 and OCT2 are major determinants of the anticancer activity of oxaliplatin and may contribute to its antitumor specificity and strongly suggest that expression of OCTs in tumors should be investigated as markers for selecting specific platinum-based therapies in individual patients.

TL;DR: A molecular platform for dual-function fluorescence/MRI sensing of mobile zinc with strategically attached porphyrin template is reported, anticipating that in vivo applications of the probes will facilitate a deeper understanding of the physiological roles of zinc and allow detection of abnormal zinc homeostasis for pathological diagnoses.

TL;DR: This work establishes the use of ILs for simultaneous enhancement of topical drug delivery and antibiotic activity, and choline-geranate emerged as a multipurpose IL with excellent antimicrobial activity, minimal toxicity to epithelial cells as well as skin, and effective permeation enhancement for drug delivery.

TL;DR: Unique chemical and biological properties of a cationic monofunctional platinum(II) complex, cis-diammine(pyridine)chloroplatinum(II), cis-[Pt(NH3)2(py)Cl]+ or cDPCP, a coordination compound previously identified to have significant anticancer activity in a mouse tumor model, merit consideration for treating colorectal and other cancers bearing appropriate cation transporters.