K
Kathleen L. Baird
Researcher at National Institutes of Health
Publications - 6
Citations - 890
Kathleen L. Baird is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 5, co-authored 6 publications receiving 887 citations. Previous affiliations of Kathleen L. Baird include Brigham and Women's Hospital & Joslin Diabetes Center.
Papers
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Journal ArticleDOI
Direct demonstration that receptor crosslinking or aggregation is important in insulin action.
TL;DR: The data suggest that receptor occupancy by ligand is not sufficient for signal generation and that the insulin-like effects of antireceptor antibody (and perhaps insulin itself) require receptor aggregation or clustering.
Journal ArticleDOI
Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes: STUDIES OF INSULIN BINDING AND INSULIN ACTION
TL;DR: The data suggest that the antibodies present in these three sera bind to different determinants on the insulin receptor, and these antibodies may be useful probes of receptor structure and function.
Book ChapterDOI
Insulin receptors, receptor antibodies, and the mechanism of insulin action.
C. Ronald Kahn,Kathleen L. Baird,Jeffery S. Flier,C. Grunfeld,Joan T. Harmon,Len C. Harrison,F. Andres Karlsson,M Kasuga,George L. King,Ursula Lang,Judith M. Podskalny,Emmanuel Van Obberghen +11 more
TL;DR: Insulin receptors, receptor antibodies, and the mechanism of insulin action are described, well known that insulin stimulates glucose transport, and this effect persists in membrane vesicles even after the cell is broken.
Journal ArticleDOI
Glucocorticoid-induced insulin resistance in vitro: evidence for both receptor and postreceptor defects.
TL;DR: Exposure of 3T3-L1 cells to dexamethasone, a synthetic glucocorticoid, resulted in decreased binding of insulin to its receptor and decreased insulin stimulation of 2-deoxyglucose uptake, and the magnitude of these changes was concentration dependent over a range of 0.1 –100 nM dexamETHasone.
Journal ArticleDOI
Role of valence and the cytoskeleton in the insulin-like activity of concanavalin A
TL;DR: The roles of ligand valence and an intact cytoskeleton in the insulin-like action of con A, a lectin derived from the jackbean, are defined.