K
Kathleen L. Gould
Researcher at Vanderbilt University
Publications - 233
Citations - 15753
Kathleen L. Gould is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Schizosaccharomyces pombe & Cytokinesis. The author has an hindex of 69, co-authored 206 publications receiving 15016 citations. Previous affiliations of Kathleen L. Gould include University of California, San Diego & University of Washington.
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Journal ArticleDOI
Identification of cold-sensitive mutations in the Schizosaccharomyces pombe actin locus.
TL;DR: Four new cold‐sensitive actin mutations are described, which affect one structure or the other, and should be useful for future studies on the role of actin itself in the function of these F‐actin‐containing structures in S. pombe.
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The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole.
TL;DR: It is established that Hhp1/2 localize throughout the cell cycle to SPBs, as well as to the nucleus, cell tips, and division site and that this targeting strategy is conserved in human CK1δ/ε localization to centrosomes.
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Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation.
TL;DR: Results indicate that Cdk1 phosphorylation of formin Cdc12 antagonizes its interaction with Cdc15 and thereby opposes CDC12’s CR localization, consistent with a general role for Cdk 1 in inhibiting cytokinesis until chromosome segregation is complete.
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Structural organization of membrane-inserted hexamers formed by Helicobacter pylori VacA toxin
Tasia M. Pyburn,Nora J. Foegeding,Christian González-Rivera,Nathan A. McDonald,Kathleen L. Gould,Timothy L. Cover,Melanie D. Ohi +6 more
TL;DR: Surprisingly, neither VacA oligomerization nor the presence of putative transmembrane GXXXG repeats in the p33 domain is required for membrane insertion, providing new insights into the process by which VacA binds and inserts into the lipid bilayer to form membrane channels.
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Use of high specific activity StarFire oligonucleotide probes to visualize low-abundance pre-mRNA splicing intermediates in S. pombe.
TL;DR: An oligonucleotide labeling system was developed that can produce radiolabeled hybridization probes with tenfold or more higher specific activity than is obtained by traditional 5'-end-labeling with polynucleotide kinase, and was shown to be tenfold more sensitive in detecting target DNA sequences in a dot blot hybridization assay.