K
Katie Streicher
Researcher at MedImmune
Publications - 67
Citations - 2318
Katie Streicher is an academic researcher from MedImmune. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 50 publications receiving 1412 citations. Previous affiliations of Katie Streicher include Amgen.
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Journal ArticleDOI
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
Christopher E. Brightling,Pascal Chanez,Richard Leigh,Paul M. O'Byrne,Stephanie Korn,Dewei She,Richard D. May,Katie Streicher,Koustubh Ranade,Edward Piper +9 more
TL;DR: The primary endpoint was the annual asthma exacerbation rate at week 52 in the intention-to-treat population, and key secondary endpoints included prebronchodilator forced expiratory volume in 1 s (FEV1), Asthma Control Questionnaires-6 (ACQ-6), and Asthma Quality of Life Questionnaire-Standardised Version (AQLQ[S).
Journal ArticleDOI
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.
Shu Wang,Jingya Wang,Varsha Kumar,Jodi L. Karnell,Brian Naiman,Phillip S. Gross,Saifur Rahman,Kamelia Zerrouki,Richard N. Hanna,Christopher Morehouse,Nicholas Holoweckyj,Hao Liu,Zerai Manna,Raphaela Goldbach-Mansky,Sarfaraz Hasni,Richard M. Siegel,Miguel Sanjuan,Miguel Sanjuan,Katie Streicher,Michael P. Cancro,Roland Kolbeck,Rachel Ettinger +21 more
TL;DR: It is shown that a CD11chiT-bet+ B cell subset with a unique phenotype and transcriptome is increased in patients with SLE, can be expanded by IL-21, and may contribute to autoimmune responses in SLE.
Journal ArticleDOI
Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19
Myron J. Levin,Andrew Ustianowski,Stéphane De Wit,Odile Launay,Miles Avila,A. Templeton,Yuan Yuan,Seth Seegobin,A. Ellery,Dennis J. Levinson,Phil Ambery,Rosalin H. Arends,R Beavon,Kanika Dey,Pedro Garbes,Elizabeth J. Kelly,Gavin C. K. W. Koh,Karen A. Near,Kelly W Padilla,Konstantina Psachoulia,Audrey Sharbaugh,Katie Streicher,Menelas N. Pangalos,Mark T. Esser +23 more
TL;DR: A single dose of AZD7442 had efficacy for the prevention of Covid-19, without evident safety concerns, and extended follow-up at a median of 6 months showed a relative risk reduction.
Journal ArticleDOI
Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab.
Brandon W. Higgs,Christopher Morehouse,Katie Streicher,Philip Brohawn,Fernanda Pilataxi,Ashok Kumar Gupta,Koustubh Ranade +6 more
TL;DR: The IFNγ+ mRNA signature may assist in identifying patients with improved outcomes with durvalumab, independent of PD-L1 assessed by IHC.
Journal ArticleDOI
Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer.
Liyan Jiang,Jiaqi Huang,Brandon W. Higgs,Zhibin Hu,Zhan Xiao,Xin Yao,Sarah Conley,Haihong Zhong,Zheng Liu,Philip Brohawn,Dong Shen,Song Wu,Xiaoxiao Ge,Yue Jiang,Yizhuo Zhao,Yuqing Lou,Chris Morehouse,Wei Zhu,Yinong Sebastian,Meggan Czapiga,Vaheh Oganesyan,Haihua Fu,Yanjie Niu,Wei Zhang,Katie Streicher,David A. Tice,Heng Zhao,Meng Zhu,Lin Xu,Ronald Herbst,Xinying Su,Yi Gu,Shyoung Li,Lihua Huang,Jianren Gu,Baohui Han,Bahija Jallal,Hongbing Shen,Yihong Yao +38 more
TL;DR: Functional studies in vitro and in vivo demonstrate that SRSF1 is important for tumorigenicity of SCLC and may play a key role in DNA repair and chemo-sensitivity and provide a rationale for personalized therapy in SclC.