Meng Zhu

TL;DR: Correlation analysis indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the Genetic etiology for the same disease can vary by population and environmental exposures.

TL;DR: Functional studies in vitro and in vivo demonstrate that SRSF1 is important for tumorigenicity of SCLC and may play a key role in DNA repair and chemo-sensitivity and provide a rationale for personalized therapy in SclC.

TL;DR: It is shown for the first time that GWAS-derived PRS can be effectively used in discriminating subpopulations at high risk of lung cancer, who might benefit from a practically feasible PRS-based lung cancer screening programme for precision prevention in Chinese populations.

TL;DR: This study integrates transcriptomics data from multiple databases and systematically identifies 876 new CT genes in 19 cancer types to propose that extremely highly expressed CT genes (EECTGs) are potential drivers activated through epigenetic mechanisms and provide methods for identifying epigenetic-driver genes of cancer, which could serve as targets of future cancer therapies.

TL;DR: It is demonstrated for the first time that common polymorphisms of H19 are associated with the risk and severity of CAD in a Chinese population and future studies are needed to explore the underlying mechanisms of the findings.