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Katja A. Lamia
Researcher at Scripps Research Institute
Publications - 45
Citations - 6041
Katja A. Lamia is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 19, co-authored 41 publications receiving 5196 citations. Previous affiliations of Katja A. Lamia include Harvard University & Scripps Health.
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Journal ArticleDOI
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Reuben J. Shaw,Reuben J. Shaw,Katja A. Lamia,Debbie S. Vasquez,Seung Hoi Koo,Seung Hoi Koo,Nabeel Bardeesy,Ronald A. DePinho,Marc Montminy,Lewis C. Cantley +9 more
TL;DR: It is shown that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels, and TORC2 is a critical target of L KB1/AMPK signals in the regulation of gluconeogenesis.
Journal ArticleDOI
Physiological significance of a peripheral tissue circadian clock
TL;DR: It is suggested that the liver clock contributes to homeostasis by driving a daily rhythm of hepatic glucose export that counterbalances the daily cycle of glucose ingestion resulting from the fasting–feeding cycle.
Journal ArticleDOI
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.
Katja A. Lamia,Uma M. Sachdeva,Luciano DiTacchio,Elliot C. Williams,Jacqueline G.A Alvarez,Jacqueline G.A Alvarez,Daniel F. Egan,Debbie S. Vasquez,Henry Juguilon,Henry Juguilon,Satchidananda Panda,Reuben J. Shaw,Reuben J. Shaw,Craig B. Thompson,Ronald M. Evans,Ronald M. Evans +15 more
TL;DR: It is demonstrated that the nutrient-responsive adenosine monophosphate–activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1), which acts as chemical energy sensors in mammals.
Journal ArticleDOI
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Katja A. Lamia,Katja A. Lamia,Stephanie J. Papp,Ruth T. Yu,Grant D. Barish,N. Henriette Uhlenhaut,Johan W. Jonker,Michael Downes,Ronald M. Evans +8 more
TL;DR: Results reveal a specific mechanism through which cryptochromes couple the activity of clock and receptor target genes to complex genomic circuits underpinning normal metabolic homeostasis.
Journal ArticleDOI
An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice
TL;DR: The results provide evidence for a previously unrecognised molecular regulator of pancreatic glucose-sensing and/or insulin secretion of pancreas explants and beta cells are very likely to be one of the pancreatic cell types possessing an intrinsic clock.