L
Luciano DiTacchio
Researcher at University of Kansas
Publications - 24
Citations - 5528
Luciano DiTacchio is an academic researcher from University of Kansas. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 15, co-authored 23 publications receiving 4586 citations. Previous affiliations of Luciano DiTacchio include Salk Institute for Biological Studies.
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Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Han Cho,Xuan Zhao,Megumi Hatori,Ruth T. Yu,Grant D. Barish,Michael T. Lam,Ling Wa Chong,Luciano DiTacchio,Annette R. Atkins,Christopher K. Glass,Christopher Liddle,Johan Auwerx,Michael Downes,Satchidananda Panda,Ronald M. Evans +14 more
TL;DR: The cistromic analysis reveals a more profound connection between BMAL1 and the REV-ERB-α and REB-β genomic regulatory circuits than was previously suspected and indicates a more integral mechanism for the coordination of circadian rhythm and metabolism.
Journal ArticleDOI
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.
Katja A. Lamia,Uma M. Sachdeva,Luciano DiTacchio,Elliot C. Williams,Jacqueline G.A Alvarez,Jacqueline G.A Alvarez,Daniel F. Egan,Debbie S. Vasquez,Henry Juguilon,Henry Juguilon,Satchidananda Panda,Reuben J. Shaw,Reuben J. Shaw,Craig B. Thompson,Ronald M. Evans,Ronald M. Evans +15 more
TL;DR: It is demonstrated that the nutrient-responsive adenosine monophosphate–activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1), which acts as chemical energy sensors in mammals.
Journal ArticleDOI
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Christopher Vollmers,Shubhroz Gill,Luciano DiTacchio,Sandhya R. Pulivarthy,Hiep D. Le,Satchidananda Panda +5 more
TL;DR: It is shown that both temporal pattern of food intake and the circadian clock drive rhythmic transcription, thereby highlighting temporal regulation of hepatic transcription as an emergent property of the circadian system.
Journal ArticleDOI
Harmonics of Circadian Gene Transcription in Mammals
Michael E. Hughes,Luciano DiTacchio,Kevin R. Hayes,Christopher Vollmers,S. Pulivarthy,Julie E. Baggs,Satchidananda Panda,John B. Hogenesch +7 more
TL;DR: These studies illustrate the importance of time sampling with respect to multiple testing, suggest caution in use of autonomous cellular models to study clock output, and demonstrate the existence of harmonics of circadian gene expression in the mouse.