D
Debbie S. Vasquez
Researcher at Salk Institute for Biological Studies
Publications - 9
Citations - 9427
Debbie S. Vasquez is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: AMPK & AMP-activated protein kinase. The author has an hindex of 8, co-authored 9 publications receiving 8458 citations. Previous affiliations of Debbie S. Vasquez include Harvard University.
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Journal ArticleDOI
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M. Gwinn,David B. Shackelford,Daniel F. Egan,Maria M. Mihaylova,Annabelle Mery,Debbie S. Vasquez,Benjamin E. Turk,Reuben J. Shaw +7 more
TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.
Journal ArticleDOI
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan,David B. Shackelford,Maria M. Mihaylova,Sara Gelino,Rebecca A. Kohnz,William B. Mair,Debbie S. Vasquez,Aashish Joshi,Dana M. Gwinn,Rebecca C. Taylor,John M. Asara,James A. J. Fitzpatrick,Andrew Dillin,Benoit Viollet,Mondira Kundu,Malene Hansen,Reuben J. Shaw +16 more
TL;DR: Reconstitution of ULK1-deficient cells with a mutant ULK2 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation.
Journal ArticleDOI
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Reuben J. Shaw,Reuben J. Shaw,Katja A. Lamia,Debbie S. Vasquez,Seung Hoi Koo,Seung Hoi Koo,Nabeel Bardeesy,Ronald A. DePinho,Marc Montminy,Lewis C. Cantley +9 more
TL;DR: It is shown that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels, and TORC2 is a critical target of L KB1/AMPK signals in the regulation of gluconeogenesis.
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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.
Katja A. Lamia,Uma M. Sachdeva,Luciano DiTacchio,Elliot C. Williams,Jacqueline G.A Alvarez,Jacqueline G.A Alvarez,Daniel F. Egan,Debbie S. Vasquez,Henry Juguilon,Henry Juguilon,Satchidananda Panda,Reuben J. Shaw,Reuben J. Shaw,Craig B. Thompson,Ronald M. Evans,Ronald M. Evans +15 more
TL;DR: It is demonstrated that the nutrient-responsive adenosine monophosphate–activated protein kinase (AMPK) phosphorylates and destabilizes the clock component cryptochrome 1 (CRY1), which acts as chemical energy sensors in mammals.
Journal ArticleDOI
LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
David B. Shackelford,David B. Shackelford,Evan R. Abt,Laurie Gerken,Debbie S. Vasquez,Atsuko Seki,Mathias Leblanc,Liu Wei,Michael C. Fishbein,Johannes Czernin,Paul S. Mischel,Reuben J. Shaw +11 more
TL;DR: Phenformin is suggested as a cancer metabolism-based therapeutic to selectively target LKB1-deficient tumors, resulting in prolonged survival in these tumors.