K
Katrin Szardenings
Researcher at Siemens
Publications - 8
Citations - 174
Katrin Szardenings is an academic researcher from Siemens. The author has contributed to research in topics: Matrix metalloproteinase inhibitor & Caspase 3. The author has an hindex of 5, co-authored 8 publications receiving 151 citations.
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Journal ArticleDOI
Repeatability of hypoxia PET imaging using [18F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial
Catharina M.L. Zegers,Wouter van Elmpt,Katrin Szardenings,Hartmuth C. Kolb,Alan D. Waxman,Rathan M. Subramaniam,Rathan M. Subramaniam,Dae Hyuk Moon,Jacqueline Brunetti,Shyam Srinivas,Philippe Lambin,David Chien +11 more
TL;DR: Repeated hypoxia PET scans with [18F]HX4 provide reproducible and spatially stable results in patients with head and neck cancer and patients with lung cancer and has the potential to aid hypoxic-targeted treatments.
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Atherosclerotic plaque uptake of a novel integrin tracer 18F-Flotegatide in a mouse model of atherosclerosis
Helen Su,Natalia Gorodny,Luis F. Gomez,Umesh B. Gangadharmath,Fanrong Mu,Gang Chen,Joseph C. Walsh,Katrin Szardenings,Daniel S. Berman,Hartmuth C. Kolb,Balaji Tamarappoo +10 more
TL;DR: It is hypothesize that Flotegatide may be a useful tracer for visualization of inflamed plaque in clinical subjects with atherosclerosis and may have potential for detecting vulnerable plaque.
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Noninvasive Molecular Imaging of Apoptosis in a Mouse Model of Anthracycline-Induced Cardiotoxicity
Helen Su,Natalia Gorodny,Luis F. Gomez,Umesh B. Gangadharmath,Fanrong Mu,Gang Chen,Joseph C. Walsh,Katrin Szardenings,Hartmuth C. Kolb,Balaji Tamarappoo +9 more
TL;DR: In a mouse model of cardiotoxicity, doxorubicin treatment is associated with increased myocardial caspase 3 expression and an increase in CP18 uptake, and 18F-CP18 may be useful for detection of anthracycline-inducedMyocardial apoptosis.
Journal ArticleDOI
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation.
Verena Hugenberg,Burkhard Riemann,Sven Hermann,Otmar Schober,Michael Schäfers,Katrin Szardenings,Artem Y. Lebedev,Umesh B. Gangadharmath,Hartmuth C. Kolb,Joseph C. Walsh,Wei Zhang,Klaus Kopka,Stefan Wagner +12 more
TL;DR: The inverse triazole-substituted MMPIs are excellent inhibitors with promising in vivo properties and Pharmacokinetic properties and metabolic stability of an (18)F-labeled candidate in mice were investigated.
Journal ArticleDOI
Radiolabeled hydroxamate-based matrix metalloproteinase inhibitors: How chemical modifications affect pharmacokinetics and metabolic stability
Verena Hugenberg,Sven Hermann,Fabian Galla,Michael Schäfers,Bernhard Wünsch,Hartmuth C. Kolb,Katrin Szardenings,Artem Y. Lebedev,Joseph C. Walsh,Vani P. Mocharla,Umesh B. Gangadharmath,Klaus Kopka,Stefan Wagner +12 more
TL;DR: The introduction of hydrophilic groups such as mini-PEG and 1,2,3-triazole-1-yl-methyl substituted MMPI was found to be the most stable candidate in this series and should be chosen for further preclinical evaluation.