K
Katsunori Nakano
Researcher at National Institutes of Health
Publications - 3
Citations - 4311
Katsunori Nakano is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Caspase 3. The author has an hindex of 3, co-authored 3 publications receiving 4037 citations.
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PUMA, a novel proapoptotic gene, is induced by p53.
TL;DR: A novel gene named PUMA (p53 upregulated modulator of apoptosis) is identified as a target for activation by p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Journal ArticleDOI
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
TL;DR: expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.
Journal ArticleDOI
A ribonucleotide reductase gene is a transcriptional target of p53 and p73.
TL;DR: The identification of a close relative of ribonucleotide reductase, recently named p53R2, as a p53-inducible gene, supports a direct role for p53 in DNA repair, in addition to inhibition of growth of damaged cells.