Katsuyoshi Takata

TL;DR: The present results show that ocular adnexal IgG4‐related disease has uniform clinicopathology: that is, disease involving the bilateral lacrimal glands with lymphoid hyperplasia and fibrosis, but not the conjunctiva, and presence of immunoglobulin heavy chain gene rearrangement suggests the possibility of B‐cell lymphoma arising in a background of IgG 4‐related chronic inflammation.

TL;DR: Clinical and pathologic findings of nine patients with systemic IgG4-related lymphadenopathy showed pathologic features only partially overlapping those of multicentric Castleman's disease, and serum data are useful for differentiating the two.

TL;DR: The history, autoimmune pancreatitis (AIP), IgG4‐related lymphadenopathy and lymphomagenesis based upon ocular adnexal IgG 4‐related disease are described and lymphoplasmacytic sclerosing pancreatitis, a prototypal histological type of AIP, is now recognized as a systemic IgG3‐ related disease.

TL;DR: A clinically and biologically distinct subgroup of tumors within GCB-DLBCL characterized by a gene expression signature of HGBL-DH/TH- BCL2 is defined by an assay applicable to routinely available biopsy samples, which enables exploration of its utility to guide patient management.

TL;DR: The paradigmatic restoration of MHC expression by EZH2 inhibitors provides the rationale for synergistic therapies combining immunotherapies with epigenetic reprogramming to enhance tumor recognition and elimination.