A Treatise on the Family. G. S. Becker. Cambridge, MA: Harvard University Press. 1981. Gary Becker is one of the most famous and influential economists of the second half of the 20th century, a fervent contributor to and expounder of the University of Chicago free-market philosophy, and winner of the 1992 Nobel Prize in economics. Although any book with the word "treatise" in its title is clearly intended to have an impact, one coming from someone as brilliant and controversial as Becker certainly had such a lofty goal. It has received many article-length reviews in several disciplines (Ben-Porath, 1982; Bergmann, 1995; Foster, 1993; Hannan, 1982), which is one measure of its scholarly importance, and yet its impact is, I think, less than it may have initially appeared, especially for scholars with substantive interests in the family. This book is, its title notwithstanding, more about economics and the economic approach to behavior than about the family. In the first sentence of the preface, Becker writes "In this book, I develop an economic or rational choice approach to the family." Lest anyone accuse him of focusing on traditional (i.e., material) economics topics, such as family income, poverty, and labor supply, he immediately emphasizes that those topics are not his focus. "My intent is more ambitious: to analyze marriage, births, divorce, division of labor in households, prestige, and other non-material behavior with the tools and framework developed for material behavior." Indeed, the book includes chapters on many of these issues. One chapter examines the principles of the efficient division of labor in households, three analyze marriage and divorce, three analyze various child-related issues (fertility and intergenerational mobility), and others focus on broader family issues, such as intrafamily resource allocation. His analysis is not, he believes, constrained by time or place. His intention is "to present a comprehensive analysis that is applicable, at least in part, to families in the past as well as the present, in primitive as well as modern societies, and in Eastern as well as Western cultures." His tone is profoundly conservative and utterly skeptical of any constructive role for government programs. There is a clear sense of how much better things were in the old days of a genderbased division of labor and low market-work rates for married women. Indeed, Becker is ready and able to show in Chapter 2 that such a state of affairs was efficient and induced not by market or societal discrimination (although he allows that it might exist) but by small underlying household productivity differences that arise primarily from what he refers to as "complementarities" between caring for young children while carrying another to term. Most family scholars would probably find that an unconvincingly simple explanation for a profound and complex phenomenon. What, then, is the salient contribution of Treatise on the Family? It is not literally the idea that economics could be applied to the nonmarket sector and to family life because Becker had already established that with considerable success and influence. At its core, microeconomics is simple, characterized by a belief in the importance of prices and markets, the role of self-interested or rational behavior, and, somewhat less centrally, the stability of preferences. It was Becker's singular and invaluable contribution to appreciate that the behaviors potentially amenable to the economic approach were not limited to phenomenon with explicit monetary prices and formal markets. Indeed, during the late 1950s and throughout the 1960s, he did undeniably important and pioneering work extending the domain of economics to such topics as labor market discrimination, fertility, crime, human capital, household production, and the allocation of time. Nor is Becker's contribution the detailed analyses themselves. Many of them are, frankly, odd, idiosyncratic, and off-putting. …

A Treatise on the Family

Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The family comprises both membrane-bound and soluble isoforms that are expressed in nearly all cell types. They are regulated by diverse extracellular agonists that include peptide hormones, bacterial toxins, and free radicals, as well as intracellular molecules, such as calcium and adenine nucleotides. Stimulation of guanylyl cyclases and the resultant accumulation of cGMP regulates complex signaling cascades through immediate downstream effectors, including cGMP-dependent protein kinases, cGMP-regulated phosphodiesterases, and cyclic nucleotide-gated ion channels. Guanylyl cyclases and cGMP-mediated signaling cascades play a central role in the regulation of diverse (patho)physiological processes, including vascular smooth muscle motility, intestinal fluid and electrolyte homeostasis, and retinal phototransduction. Topics addressed in this review include the structure and chromosomal localization of the genes for guanylyl cyclases, structure and function of the members of the guanylyl cyclase family, molecular mechanisms regulating enzymatic activity, and molecular sequences coupling ligand binding to catalytic activity. A brief overview is presented of the downstream events controlled by guanylyl cyclases, including the effectors that are regulated by cGMP and the role that guanylyl cyclases play in cell physiology and pathophysiology.

Guanylyl Cyclases and Signaling by Cyclic GMP

Interpersonal relations — a theory of interdependence

The Case for Marriage: Why Married People are Happier, Healthier, and Better Off Financially. Linda J. Waite & Maggie Gallagher. New York: Doubleday. 2000. 260 pp. ISBN 0-38550085-8. $24.95 cloth. Marriage, our second oldest institution, has been controversial during most of its existence. In The Bankruptcy of Marriage, Calverton (1928) observed, "It is marriage as we know it... the marriage of modern monogamy, of the bindingcontract variety, our system of marriage, in other words, that has broken down, and to-day is bankrupt" (p. 62). Given its age and its undisputed importance, marriage has long been challenged and defended. The Case for Marriage offers a spirited and well-documented but flawed example of such a defense. First, its use of language is far from neutral. Its tone oozes with disrespect for those who deviate from lifelong marriage. Marriage throughout the text is referred to as a "bargain," a superior investment benefiting both those who participate and society at large. Cohabitation, on the other hand, is a "deal," something one picks up at a flea market. Cohabiting partners, regardless of their age, are referred to as "live-in" boy- or girlfriends and are described as "couples living together without commitment" (p. 190). Adult singles are treated as a residual category. As constructionists remind us, the use of language is not just a descriptive but a creative and frequently assertive activity. My second concern is conceptual. Marriage institutionalizes the legitimacy of offspring in human societies. Children born in it, regardless of its form, are considered "legitimate" and belong to a kinship network. The marriage institution, then, has a clear stake in its procreative consequences, as is exemplified by its sole universal rule, the "incest taboo." Its main "enemy" is promiscuous reproduction. Its "allies" are those other forms of "living together" that, regardless of their duration, counter random mating. "Family," the oldest human institution, traditionally is responsible for "caring" for the very young, and nowadays also for the aged. It seems impossible to imagine humanity's pilgrimage without these two institutions. It is quite possible, however, to imagine each one taking on a variety of forms. The core units of the marriage and family institutions are, respectively, married couples and family networks. The bulk of Waite's and Gallagher's book is not about the institutions of marriage and family, but rather about individuals who choose to participate in marital and familial units. They conceptualize marriage as more than a "private emotional relationship" and specify a "lifelong commitment to form a new family" (p. 187) as its raison d'etre. They use the words marriage and family interchangeably. This is confusing. For example, are voluntarily childless married couples to be considered deviants? Uncommitted? What about one-parent families? Are they a different legitimate family form or, as the authors seem to imply, simply an outcome of unwed motherhood, marital failure, or early spousal death? I agree with the authors that marriage's "larger public role must be acknowledged and supported by the larger society and its institutions" (p. 187). All social arrangements, whether sacred or profane, to use Durkheim's terminology, that combat reproductive promiscuity or inadequate family care deserve support from "society and its institutions." The authors' treatment of cohabitation is equally troublesome to me. Analytically, cohabitation, in its many manifestations, should not be contrasted or compared with marriage but rather with the equally diverse category of singlehood. I have no problem with the multitude of quantitative data amassed by the authors to show that enduring marriages and families, on the average, offer some distinct advantages over cohabitation. …

The Case for Marriage: Why Married People Are Happier, Healthier, and Better off Financially

ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and formation of the strong oxidant peroxynitrite. Increased oxidative stress affects the heme-containing NO receptor sGC by both decreasing its expression levels and impairing NO-induced activation, making vasodilator therapy with NO donors less effective. Here we show in vivo that oxidative stress and related vascular disease states, including human diabetes mellitus, led to an sGC that was indistinguishable from the in vitro oxidized/heme-free enzyme. This sGC variant represents what we believe to be a novel cGMP signaling entity that is unresponsive to NO and prone to degradation. Whereas high-affinity ligands for the unoccupied heme pocket of sGC such as zinc–protoporphyrin IX and the novel NO-independent sGC activator 4-[((4-carboxybutyl){2-[(4-phenethylbenzyl)oxy]phenethyl}amino) methyl [benzoic]acid (BAY 58-2667) stabilized the enzyme, only the latter activated the NO-insensitive sGC variant. Importantly, in isolated cells, in blood vessels, and in vivo, BAY 58-2667 was more effective and potentiated under pathophysiological and oxidative stress conditions. This therapeutic principle preferentially dilates diseased versus normal blood vessels and may have far-reaching implications for the currently investigated clinical use of BAY 58-2667 as a unique diagnostic tool and highly innovative vascular therapy.

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Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels

This work examines what role children play in the re-partnering process in five European countries (Norway, France, Germany, Romania, and the Russian Federation) by addressing the following research questions: (1) To what extent do men and women differ in their re-partnering chances?; (2) Can gender differences in re-partnering be explained by the presence of children?; (3) How do the custodial arrangements and the child’s age affect the re-partnering chances of men and women? We use the partnership and parenthood histories of the participants in the first wave of the Generations and Gender Survey (United Nations, Generations and Gender Programme: Survey Instruments. United Nations, New York/Geneva, 2005) to examine the transition to moving in with a new partner following the dissolution of the first marital union, separately for men and women. The story that emerges is one of similarities in the effects rather than differences. In most countries, men are more likely to re-partner than women. This gender difference can be attributed to the presence of children as our analyses show that childless men and women do not differ in their probability to re-partner. Mothers with resident children are less likely to re-partner than non-mothers and a similar though often non-significant effect of resident children is observed for fathers. In most countries we find that as the child ages, the chances to enter a new union increase. In sum, our study indicates that children are an important factor in re-partnering and a contributor to the documented gender gap in re-partnering, and this holds throughout distinct institutional and cultural settings.

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The effect of children on men's and women's chances of re-partnering in a European context

The aim of the present study was to explore whether nitric oxide (NO) interferes with the attachment of human melanocytes to the extracellular matrix (ECM) components. Consequently, the effects have been investigated of the NO-releasing compounds 3-morpholino-sydnonimine (SIN-1) and S-nitroso-glutathione (GSNO) on the in vitro adhesion of human melanocytic cells to fibronectin. The NO donors induced a concentration-dependent reduction in the adhesion of both 51CrO4(2-)-labelled melanocytes and melanoma cells to fibronectin. Pigmented M14 melanoma cells were more susceptible to the effect of SIN-1 (half-maximal inhibiting effect at about 0.5 mM) than normal human melanocytes and also than the non-pigmented melanoma cells Mel57 (half-maximal inhibiting effects between 0.9 and 2 mM). This effect of SIN-1 also appeared to be related to the melanin content of normal melanocytes, whereas GSNO was significantly less active. Both flow cytometric analysis and immunocytochemical staining showed expression of neuronal NO synthase in all cell lines. The results of this study suggest that aberrant in vivo production of NO during infection and inflammation may contribute to loss of melanocytes in, for example, vitiligo, by reducing de novo attachment of melanocytes to the ECM. These findings could also be important for understanding the process of metastasis.

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Effects of nitric oxide on the adhesion of human melanocytes to extracellular matrix components

As a result of the divorce revolution, more children grow up in complex families. Yet, we know little about how family complexity affects relationships when children are adults and parents are agei...

https://journals.sagepub.com/doi/pdf/10.1177/0003122419871959

Family Complexity into Adulthood: The Central Role of Mothers in Shaping Intergenerational Ties:

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'From parents to partners: the impact of family on romantic relationships in adolescence and emerging adulthood

This data brief gives an overview of the background, design, and content of the multi-actor OKiN survey (Ouders en Kinderen in Nederland; Parents and Children in The Netherlands). The purpose of OKiN is to examine the individual consequences of family complexity for intergenerational relations, intergenerational reproduction, and individual health and well-being. Another goal of OKiN is to generate detailed and nationally representative descriptive information on the types and degrees of family complexity that contemporary adult generations in The Netherlands (adults born between 1971 and 1991) have experienced when they were growing up. Unique features of the OKiN data are (i) the oversample of persons who grew up with separated and/or widowed parents, and persons who grew up with a step-parent; (ii) the double multi-actor design (i.e. primary respondents (anchors) report about multiple parent figures and parent figures (alters) report about multiple children); and (iii) the systematic probing of relations to and characteristics of all parent figures in the respondent’s life. The brief provides the first descriptive findings about the OKiN respondents.

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Katya Ivanova

Papers

The effect of children on men's and women's chances of re-partnering in a European context

Effects of nitric oxide on the adhesion of human melanocytes to extracellular matrix components

Family Complexity into Adulthood: The Central Role of Mothers in Shaping Intergenerational Ties:

'From parents to partners: the impact of family on romantic relationships in adolescence and emerging adulthood

A Multi-Actor Study of Adult Children and Their Parents in Complex Families : Design and Content of the OKiN Survey