Kausar Alam

TL;DR: This study identified and characterized phthalocyanine tetrasulfonic acid RecA inhibitors that block antibiotic-induced activation of the SOS response and provides a new strategy for prolonging antibiotic shelf life.

TL;DR: A new way to construct recombinant antibody‐like “ devices” by using a bottom‐up approach to build them from well‐behaved discrete recombinant antibodies domains or “parts”, thereby creating devices with desired properties based on summed properties of parts and in configurations that cannot be obtained by using genetic engineering.

TL;DR: Galf immunolocalization using the L10 monoclonal antibody showed that ugmA deletion and repression phenotypes correlated with loss of hyphal wall Galf, and none of the gene manipulations affected itraconazole sensitivity, as expected.

TL;DR: A phage‐displayed antigen‐binding fragment (Fab) library built on a modified trastuzumab framework with four fixed and two diversified complementarity‐determining regions (CDRs) is described, which was used to conduct selections against the human epidermal growth factor receptor‐3 extracellular domain and compared the CDR diversity of the naïve library and the anti‐HER3 selection pool by use of next‐generation sequencing.

TL;DR: Results indicated that A. nidulans strains containing mutated AfugmA showed increased sensitivity to antifungal drugs, particularly Caspofungin, and reduced β-glucan content was correlated with increased Casp ofungin sensitivity.