Kay-Obbe Voss

TL;DR: This work demonstrates that H2AX is early phosphorylated within HC, but the damage site is subsequently expelled from the center to the periphery of chromocenters within ∼20 min, and describes a local decondensation of HC at the sites of ion hits, potentially allowing for DSB movement via physical forces.

TL;DR: In this paper, a conical-shaped polyethylene terephthalate (PET) and polyimide foils were prepared by applying the track-etching technique, where a thin polymer foil was penetrated by a single heavy ion (e.g. Au, Bi, U) of total kinetic energy of several hundred MeV to some GeV.

TL;DR: It is shown that a transient dose-dependent activation of the kinases occurring on complex DNA lesions leads to their nuclear-wide distribution and H2AX phosphorylation, yet without eliciting a full pan-nuclear DNA damage response.

TL;DR: The observation of morphology-dependent resonances in the Raman scattering from a train of perfectly uniform water droplets allows us to measure the variation in droplet size resulting from evaporative mass losses with an absolute precision of better than 0.2% and proves crucial to an unambiguous determination of the droplet temperature.

TL;DR: This work examines the DSB repair at the facultative heterochromatin of the inactive X chromosome (Xi) in humans using heavy ion irradiation to verify that the relocation process is conserved between species and not specialised to repetitive sequences only.