G
Gisela Taucher-Scholz
Researcher at Technische Universität Darmstadt
Publications - 74
Citations - 4094
Gisela Taucher-Scholz is an academic researcher from Technische Universität Darmstadt. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 33, co-authored 73 publications receiving 3647 citations. Previous affiliations of Gisela Taucher-Scholz include Darmstadt University of Applied Sciences.
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Journal ArticleDOI
Factors determining DNA double-strand break repair pathway choice in G2 phase.
Atsushi Shibata,Sandro Conrad,Julie Birraux,Verena Geuting,Olivia Barton,A. A. Ismail,Andreas Kakarougkas,Katheryn Meek,Gisela Taucher-Scholz,Markus Löbrich,Penny A. Jeggo +10 more
TL;DR: It is proposed that NHEJ initially attempts to repair DSBs and, if rapid rejoining does not ensue, then resection occurs promoting repair by HR, and novel roles for ATM in regulating DSB end resection are identified.
Journal ArticleDOI
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
Naoya Uematsu,Eric Weterings,Ken Ichi Yano,Keiko Morotomi-Yano,Burkhard Jakob,Gisela Taucher-Scholz,Pierre Olivier Mari,Dik C. van Gent,Benjamin P C Chen,David J. Chen +9 more
TL;DR: A model in which DNA-PKCS phosphorylation/autophosphorylation facilitates NHEJ by destabilizing the interaction of DNA- PKCS with the DNA ends is suggested.
Journal ArticleDOI
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
Burkhard Jakob,Jörn Splinter,Sandro Conrad,Kay-Obbe Voss,Daniele Zink,Marco Durante,Markus Löbrich,Gisela Taucher-Scholz +7 more
TL;DR: This work demonstrates that H2AX is early phosphorylated within HC, but the damage site is subsequently expelled from the center to the periphery of chromocenters within ∼20 min, and describes a local decondensation of HC at the sites of ion hits, potentially allowing for DSB movement via physical forces.
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Autophosphorylation and ATM Activation: ADDITIONAL SITES ADD TO THE COMPLEXITY*
Sergei Kozlov,Mark E. Graham,Burkhard Jakob,Frank Tobias,Amanda W. Kijas,Marcel Tanuji,Philip Chen,Phillip J. Robinson,Gisela Taucher-Scholz,Keiji Suzuki,Sairai So,David J. Chen,Martin F. Lavin,Martin F. Lavin +13 more
TL;DR: This work targeted the ATM phosphorylation sites, Ser367 and Ser2996, for further study by generating phosphospecific antibodies against these sites and demonstrated thatosphorylation of both was rapidly induced by radiation, providing further support for the importance of autophosphorylated in the activation and function of ATM in vivo.
Journal ArticleDOI
Live cell microscopy analysis of radiation-induced DNA double-strand break motion
TL;DR: The hypothesis that spatial proximity of DNA breaks is required for the formation of radiation-induced chromosomal exchanges is supported, as long-range displacements of damaged chromatin domains do not generally occur during DNA double-strand break repair after introduction of multiple damaged sites by charged particles.