K
Kazufumi Honda
Researcher at Japan Agency for Medical Research and Development
Publications - 121
Citations - 4871
Kazufumi Honda is an academic researcher from Japan Agency for Medical Research and Development. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 39, co-authored 108 publications receiving 4353 citations. Previous affiliations of Kazufumi Honda include National Cancer Research Institute.
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Journal ArticleDOI
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
Kazufumi Honda,Tesshi Yamada,Ritsuko Endo,Yoshinori Ino,Masahiro Gotoh,Hitoshi Tsuda,Yozo Yamada,Hiroshige Chiba,Setsuo Hirohashi +8 more
TL;DR: It is suggested that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.
Journal ArticleDOI
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.
Kazufumi Honda,Tesshi Yamada,Yasuharu Hayashida,Masashi Idogawa,Satoshi Sato,Fumio Hasegawa,Yoshinori Ino,Masaya Ono,Setsuo Hirohashi +8 more
TL;DR: Actinin-4 actively increases cell motility and promotes lymph node metastasis of colorectal cancer.
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Label-free Quantitative Proteomics Using Large Peptide Data Sets Generated by Nanoflow Liquid Chromatography and Mass Spectrometry
Masaya Ono,Miki Shitashige,Kazufumi Honda,Tomohiro Isobe,Hideya Kuwabara,Hirotaka Matsuzuki,Setsuo Hirohashi,Tesshi Yamada +7 more
TL;DR: An integrated platform consisting of machinery and software modules that can apply vast amounts of data generated by nanoflow LC-MS to differential protein expression analyses and warrant its application to various types of experimental and translational proteomics is developed.
Journal ArticleDOI
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma.
Nobuhiro Nitori,Yoshinori Ino,Yukihiro Nakanishi,Tesshi Yamada,Kazufumi Honda,Kazuyoshi Yanagihara,Tomoo Kosuge,Yae Kanai,Masaki Kitajima,Setsuo Hirohashi +9 more
TL;DR: TF expression may contribute to the aggressiveness of pancreatic ductal adenocarcinoma by stimulating tumor invasiveness, and that evaluation of the primary tumor for TF expression may identify patients with a poor prognosis.
Journal ArticleDOI
Combined Functional Genome Survey of Therapeutic Targets for Hepatocellular Carcinoma
Reiko Satow,Miki Shitashige,Yae Kanai,Fumitaka Takeshita,Hidenori Ojima,Takafumi Jigami,Kazufumi Honda,Tomoo Kosuge,Takahiro Ochiya,Setsuo Hirohashi,Tesshi Yamada +10 more
TL;DR: The combination of genome-wide expression and functional screening described here is a rapid and comprehensive approach that could be applied in the identification of therapeutic targets in any type of human malignancy.