Takahiro Ochiya

TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.

TL;DR: The usefulness of circulating miRNA for cancer diagnosis, prognosis, and therapeutics is summarized and a mechanism for the secretion and incorporation of miRNA into the cells is proposed.

TL;DR: In this paper, the authors summarize recent developments and the current knowledge of extracellular vesicles (EVs) and discuss safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application.

TL;DR: It is demonstrated that the neutral sphyngomyelinase 2 (nSMase2) regulates exosomal microRNA (miRNA) secretion and promotes angiogenesis within the tumor microenvironment as well as metastasis, suggesting that the horizontal transfer of exosome miRNAs from cancer cells can dictate the microenviromental niche for the benefit of the cancer cell.

TL;DR: Adipose tissue is a source of multipotent stem cells that can be easily isolated, selected, and induced into mature, transplantable hepatocytes, and the fact that they are easy to procure ex vivo in large numbers makes them an attractive tool for clinical studies in the context of establishing an alternative therapy for liver dysfunction.