Kazuhide Misawa

TL;DR: It is shown that STAT5 has pleiotropic functions regulating cell proliferation, differentiation and apoptosis in an IL‐3‐dependent Ba/F3 cell line, and suggests that a single transcription factor regulates cell fate by varying the intensity and duration of the expression of a set of target genes.

TL;DR: This work has identified a constitutively active STAT5 mutant which has two amino acid substitutions; one is located upstream of the putative DNA binding domain (H299R), and the other is located in the transactivation domain (S711F) and indicated that a molecular basis for the constitutive activation is the stability of the phosphorylated form of the mutant STAT5.

TL;DR: Bone Marrow Transplantation and allogeneic skin transplantation on a lethally neutron-irradiated nuclear accident victim revealed an almost normal T cell count and immune functions were severely impaired, but the patient died from infectious complication 210 days after the accident.

TL;DR: An expression cloning method (FL-REX; fluorescence localization-based retrovirus-mediated expression cloning) in which cDNAs can be isolated based on the subcellular localization of their protein products, indicating that FL-REx is useful for identification of proteins that show specific intracellular localization.

TL;DR: In this paper, the authors investigated the effects on the autonomic nervous system of anesthesia induction with a combination of midazolam and barbiturate using plasma catecholamine concentration and heart rate (HR) variability.