K
Kazuhiro Kurasawa
Researcher at Dokkyo Medical University
Publications - 81
Citations - 2426
Kazuhiro Kurasawa is an academic researcher from Dokkyo Medical University. The author has contributed to research in topics: T cell & Eosinophil. The author has an hindex of 25, co-authored 73 publications receiving 2116 citations. Previous affiliations of Kazuhiro Kurasawa include Chiba University & Tokyo Institute of Technology.
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Journal ArticleDOI
Increased interleukin‐17 production in patients with systemic sclerosis
Kazuhiro Kurasawa,Koichi Hirose,Hideki Sano,Hideharu Endo,Hiroshi Shinkai,Nawata Y,Katsuhiko Takabayashi,Itsuo Iwamoto +7 more
TL;DR: IL-17 overproduction plays an important role in the pathogenesis of SSc, especially in the early stages of the disease, by inducing the proliferation of fibroblasts and the production of IL-1 and the expression of adhesion molecules on endothelial cells.
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Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis.
Kazuhiro Kurasawa,Satoko Arai,Yumeko Namiki,Ayae Tanaka,Yuta Takamura,Takayoshi Owada,Masafumi Arima,Reika Maezawa +7 more
TL;DR: Combination therapy with TOF might have the potential to control refractory anti-MDA5 Ab+ DM-ILD and the survival rate of patients who received TOF was significantly better than that of the historical controls with immunosuppressive therapy before TOF.
Journal Article
Corticosteroid resistant interstitial pneumonitis in dermatomyositis/polymyositis: prediction and treatment with cyclosporine.
Nawata Y,Kazuhiro Kurasawa,Katsuhiko Takabayashi,Miike S,N Watanabe,Masaki Hiraguri,Y Kita,M Kawai,Yasushi Saito,Itsuo Iwamoto +9 more
TL;DR: Corticosteroid resistant IP develops mostly in patients with DM/PM without CPK elevation at the onset of IP (type II IP), and cyclosporine is effective for the corticosteroids resistant IP inDM/PM and significantly prolongs survival of patients.
Journal Article
Primed T Cells Are More Resistant to Fas-Mediated Activation-Induced Cell Death than Naive T Cells
TL;DR: Results indicate that naive T cells are sensitive to Fas-mediated AICD and are easily deleted by Ag restimulation, while primed/memory T cells express higher levels of FLIP after Ag restIMulation, are resistant to Fas -mediated A ICD, and thus function as efficient effector cells for a longer period.
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Anti-TIF1-γ antibody and cancer-associated myositis: A clinicohistopathologic study
Ayumi Hida,Takenari Yamashita,Yuji Hosono,Manami Inoue,Kenichi Kaida,Masato Kadoya,Yusuke Miwa,Nobuyuki Yajima,Reika Maezawa,Satoko Arai,Kazuhiro Kurasawa,Kazuhiro Ito,Hiroyuki Shimada,Tomoko Iwanami,Masahiro Sonoo,Yuki Hatanaka,Shigeo Murayama,Ayumi Uchibori,Atsuro Chiba,Hitoshi Aizawa,Takayuki Momoo,Yoshiharu Nakae,Yasuhisa Sakurai,Yasushi Shiio,Hideji Hashida,Toshihiro Yoshizawa,Yoshio Sakiyama,Aya Oda,Kiyoharu Inoue,Sousuke Takeuchi,Nobue K. Iwata,Hidetoshi Date,Naoki Masuda,Takashi Mikata,Yasufumi Motoyoshi,Yoshikazu Uesaka,Meiko Hashimoto Maeda,Ran Nakashima,Shoji Tsuji,Shin Kwak,Tsuneyo Mimori,Jun Shimizu +41 more
TL;DR: CAM includes clinicohistopathologically heterogeneous disease entities and has characteristically shown a close temporal association with cancer detection and the histopathologic findings of dC5b-9 and VFs, and CAM with NAM is a subset of anti-TIF1-&ggr;-Ab(−) CAM.