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Kazuei Igarashi

Researcher at Chiba University

Publications -  465
Citations -  19382

Kazuei Igarashi is an academic researcher from Chiba University. The author has contributed to research in topics: Spermidine & Spermine. The author has an hindex of 68, co-authored 457 publications receiving 18191 citations. Previous affiliations of Kazuei Igarashi include University of Washington & Jikei University School of Medicine.

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Journal ArticleDOI

Polyamines: Mysterious Modulators of Cellular Functions

Kazuei Igarashi, +1 more
- 19 May 2000 - 
TL;DR: Polyamines were found to modulate protein synthesis at several different levels including stimulation of special kinds of protein synthesis, stimulation of the assembly of 30 S ribosomal subunits and stimulation of Ile-tRNA formation.
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Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins.

Yaeta Endo, +5 more
- 01 Jan 1988 - 
TL;DR: Results indicate that both VT2 and Shiga toxin inactivate 60S ribosomal subunits by cleaving the N-glycosidic bond at A-4324 in 28S ribOSomal RNA.
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Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination.

Yasuko Murakami, +7 more
- 10 Dec 1992 - 
TL;DR: It is demonstrated that immunodepletion of proteasomes from cell extracts causes almost complete loss of ATP-and antizyme-dependent degradation of ODC, suggesting that the 26S proteasome, widely viewed as specific for ubiquitin-conjugated proteins, is the main enzyme responsible for ODC degradation.
Journal ArticleDOI

Modulation of cellular function by polyamines

Kazuei Igarashi, +1 more
- 01 Jan 2010 - 
TL;DR: The major focus on this review is on the role of polyamines in protein synthesis, and effects of polyamine oxidases on B to Z conversion of DNA, transcription, phosphorylation of proteins, cell cycle progression, apoptosis and ion channels.
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Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans.

Kiyoshi Terao, +7 more
- 01 Jul 1994 - 
TL;DR: It was clearly demonstrated that cylindrospermopsin is a potent inhibitor of the protein synthesis and the amount of total P450 was extensively diminished in the toxin treated with hepatic microsomes.