K
Kazuhisa Nakao
Researcher at Tokyo University of Science
Publications - 27
Citations - 1499
Kazuhisa Nakao is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Transplantation & Regenerative medicine. The author has an hindex of 12, co-authored 27 publications receiving 1392 citations.
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Journal ArticleDOI
The development of a bioengineered organ germ method
Kazuhisa Nakao,Ritsuko Morita,Yasumitsu Saji,Kentaro Ishida,Yusuke Tomita,Miho Ogawa,Masahiro Saitoh,Yasuhiro Tomooka,Takashi Tsuji +8 more
TL;DR: To bioengineer ectodermal organs such as teeth and whisker follicles, a three-dimensional organ-germ culture method is developed, which generated a structurally correct tooth, after both in vitro organ culture and transplantation under a tooth cavity in vivo.
Journal ArticleDOI
Fully functional bioengineered tooth replacement as an organ replacement therapy
Etsuko Ikeda,Ritsuko Morita,Kazuhisa Nakao,Kentaro Ishida,Takashi Nakamura,Teruko Takano-Yamamoto,Miho Ogawa,Mitsumasa Mizuno,Shohei Kasugai,Takashi Tsuji +9 more
TL;DR: A successful fully functioning tooth replacement in an adult mouse is reported through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region and this technology is proposed as a model for future organ replacement therapies.
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Functional Tooth Regeneration Using a Bioengineered Tooth Unit as a Mature Organ Replacement Regenerative Therapy
Masamitsu Oshima,Mitsumasa Mizuno,Mitsumasa Mizuno,Aya Imamura,Miho Ogawa,Masato Yasukawa,Hiromichi Yamazaki,Ritsuko Morita,Etsuko Ikeda,Kazuhisa Nakao,Teruko Takano-Yamamoto,Shohei Kasugai,Masahiro Saito,Takashi Tsuji +13 more
TL;DR: This study reports a further development in which a bioengineered tooth unit comprising mature tooth, periodontal ligament and alveolar bone was successfully transplanted into a properly-sized bony hole in the alveolars through bone integration by recipient bone remodeling in a murine transplantation model system.
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Hair organ regeneration via the bioengineered hair follicular unit transplantation
Kyosuke Asakawa,Koh-ei Toyoshima,Naoko Ishibashi,Hirofumi Tobe,Ayako Iwadate,Tatsuya Kanayama,Tomoko Hasegawa,Kazuhisa Nakao,Hiroshi Toki,Shotaro Noguchi,Miho Ogawa,Akio Sato,Akio Sato,Takashi Tsuji +13 more
TL;DR: In this paper, a bioengineered hair follicle was successfully connected to the host skin epithelium by intracutaneous transplantation and reproduced the stem cell niche and hair cycles.
Journal ArticleDOI
FGF-2 potently induces both proliferation and DSP expression in collagen type I gel cultures of adult incisor immature pulp cells.
TL;DR: It is suggested that both the presence of FGF-2 and the three-dimensional formation of immature dental pulp cells in collagen type I gel cultures are essential for both DSP expression and odontoblast differentiation.