K
Kazuo Nitta
Researcher at Tohoku Pharmaceutical University
Publications - 107
Citations - 2533
Kazuo Nitta is an academic researcher from Tohoku Pharmaceutical University. The author has contributed to research in topics: Lectin & Affinity chromatography. The author has an hindex of 26, co-authored 107 publications receiving 2388 citations. Previous affiliations of Kazuo Nitta include Mallinckrodt.
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Journal Article
Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.
Takehiko Kunimoto,Kazuo Nitta,Tomiko Tanaka,Nobuaki Uehara,Hiroyasu Baba,Mieko Takeuchi,Teruo Yokokura,Siego Sawada,Tadashi Miyasaka,Masahiko Mutai +9 more
TL;DR: CPT-11 showed significant antitumor activity against a broad spectrum of experimental tumor models by i.p., i.v., or oral administration, giving the highest maximum increase in life span (ILS) and showing good activity over a wide dose range.
Journal ArticleDOI
Carbohydrate structure and differential binding of prostate specific antigen to Maackia amurensis lectin between prostate cancer and benign prostate hypertrophy.
Chikara Ohyama,Masahiro Hosono,Kazuo Nitta,Masayoshi Oh-eda,Kazuyuki Yoshikawa,Tomonori Habuchi,Yoichi Arai,Minoru Fukuda +7 more
TL;DR: The results suggest that the differential binding of free serum PSA to M. amurensis agglutinin lectin between prostate cancer and benign prostate hypertrophy could be a potential measure for diagnosis of prostate cancer.
Journal Article
Dependence on chain length of antitumor activity of (1 leads to 3)-beta-D-glucan from Alcaligenes faecalis var. myxogenes, IFO 13140, and its acid-degraded products.
TL;DR: The results from the bioassay study of the low-molecular-weight (1 leads to 3)-beta-D-glucans prepared from the glucan with number-average degrees of polymerization (DPn) 540 by hydrolysis with formic acid or sulfuric acid showed that the glucans with DPn greater than 50 inhibited the growth of Sarcoma 180 implanted s.c. in mice.
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Tandem repeat structure of rhamnose-binding lectin from catfish (Silurus asotus) eggs
Masahiro Hosono,Kazunori Ishikawa,Reiko Mineki,Kimie Murayama,Chifumi Numata,Yukiko Ogawa,Yoshio Takayanagi,Kazuo Nitta +7 more
TL;DR: The results show that RBLs including SAL comprise a family of alpha-galactosyl binding lectins having characteristic tandem repeat domain structures.
Journal ArticleDOI
A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells
Yuki Fujii,Naoshi Dohmae,Koji Takio,Sarkar M. A. Kawsar,Sarkar M. A. Kawsar,Ryo Matsumoto,Imtiaj Hasan,Imtiaj Hasan,Yasuhiro Koide,Robert A. Kanaly,Hidetaro Yasumitsu,Yukiko Ogawa,Shigeki Sugawara,Masahiro Hosono,Kazuo Nitta,Jiharu Hamako,Taei Matsui,Yasuhiro Ozeki +17 more
TL;DR: MytiLec is the first reported lectin having a primary structure with the highly novel triple tandem-repeat domain and showing transduction of apoptotic signaling against Burkitt lymphoma cells by interaction with a glycosphingolipid-enriched microdomain containing Gb3.