Y
Yuki Fujii
Researcher at Nagasaki International University
Publications - 55
Citations - 788
Yuki Fujii is an academic researcher from Nagasaki International University. The author has contributed to research in topics: Lectin & Affinity chromatography. The author has an hindex of 13, co-authored 55 publications receiving 502 citations. Previous affiliations of Yuki Fujii include Yokohama City University & University of Minnesota.
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Journal ArticleDOI
A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells
Yuki Fujii,Naoshi Dohmae,Koji Takio,Sarkar M. A. Kawsar,Sarkar M. A. Kawsar,Ryo Matsumoto,Imtiaj Hasan,Imtiaj Hasan,Yasuhiro Koide,Robert A. Kanaly,Hidetaro Yasumitsu,Yukiko Ogawa,Shigeki Sugawara,Masahiro Hosono,Kazuo Nitta,Jiharu Hamako,Taei Matsui,Yasuhiro Ozeki +17 more
TL;DR: MytiLec is the first reported lectin having a primary structure with the highly novel triple tandem-repeat domain and showing transduction of apoptotic signaling against Burkitt lymphoma cells by interaction with a glycosphingolipid-enriched microdomain containing Gb3.
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Isolation, purification, characterization and glycan-binding profile of a d-galactoside specific lectin from the marine sponge, Halichondria okadai
Sarkar M. A. Kawsar,Yuki Fujii,Ryo Matsumoto,Takayuki Ichikawa,Hiroaki Tateno,Jun Hirabayashi,Hidetaro Yasumitsu,Chikaku Dogasaki,Masahiro Hosono,Kazuo Nitta,Jiharu Hamako,Taei Matsui,Yasuhiro Ozeki +12 more
TL;DR: Partial primary structure analysis of 7 peptides by cleavage with lysyl endopeptidase indicated that one of the peptides showed significant similarity with galectin purified from the sponge Geodia cydonium.
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Crystal structure of MytiLec, a galactose-binding lectin from the mussel Mytilus galloprovincialis with cytotoxicity against certain cancer cell types
Daiki Terada,Fumihiro Kawai,Hiroki Noguchi,Satoru Unzai,Imtiaj Hasan,Imtiaj Hasan,Yuki Fujii,Sam-Yong Park,Yasuhiro Ozeki,Jeremy R. H. Tame +9 more
TL;DR: An engineered monomer mutant lost all cytotoxic activity against Raji cells, but retained some haemagglutination activity, showing that the quaternary structure of the protein is important for its cellular effects.
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MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt’s Lymphoma Cells to Trigger Apoptosis through Multiple Pathways
Imtiaj Hasan,Shigeki Sugawara,Yuki Fujii,Yasuhiro Koide,Daiki Terada,Naoya Iimura,Toshiyuki Fujiwara,Keisuke G. Takahashi,Nobuhiko Kojima,Sultana Rajia,Sarkar M. A. Kawsar,Robert A. Kanaly,Hideho Uchiyama,Masahiro Hosono,Yukiko Ogawa,Hideaki Fujita,Jiharu Hamako,Taei Matsui,Yasuhiro Ozeki +18 more
TL;DR: The findings indicate that the novel R-type lectin MytiLec initiates programmed cell death of Burkitt’s lymphoma cells through multiple pathways (MAPK cascade, death receptor signaling; caspase activation) based on interaction of the lectin with Gb3-containing glycosphingolipid-enriched microdomains on the cell surface.
Journal ArticleDOI
Regioselective synthesis, characterization, and antimicrobial activities of some new monosaccharide derivatives.
TL;DR: A number of test compounds showed remarkable antimicrobial activity comparable to, and in some cases even higher than, the standard antibiotics employed.