Kazushi Takahashi

TL;DR: It is concluded that cardiac parasympathetic dysfunction occurs concurrent with sympathetic denervation as revealed by (123)I-MIBG myocardial scintigraphy in PD and contributes to the development of orthostatic hypotension.

TL;DR: Appropriate recognition of levodopa-related fluctuations, both motor and non-motor, can lead to treatment modifications in Parkinson's disease patients.

TL;DR: Examining mesencephalic dopaminergic neurons of klotho mice and identifying tyrosine hydroxylase-positive neurons in the SNc and VTA found that levels of striatal dopamine were significantly decreased with aging in klOTHo mice, suggesting that abnormal activation of vitamin D due to Klotho insufficiency leads to degeneration of the dopamine system.

TL;DR: The study revealed that the prevalence of fatigue in Japanese PD patients is as high as that in Western countries, and that fatigue is a relatively independent symptom, although sleep disturbance may be associated with fatigue.

TL;DR: The aim of this work was to investigate the prevalence of camptocormia and the clinical characteristics of patients with camptOCormia in a large population of PD patients.