K
Kazuyasu Sakaguchi
Researcher at Hokkaido University
Publications - 178
Citations - 19605
Kazuyasu Sakaguchi is an academic researcher from Hokkaido University. The author has contributed to research in topics: Peptide sequence & Phosphorylation. The author has an hindex of 57, co-authored 170 publications receiving 18908 citations. Previous affiliations of Kazuyasu Sakaguchi include Brookhaven College & Brookhaven National Laboratory.
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Journal ArticleDOI
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Christine E. Canman,Dae-Sik Lim,Karlene A. Cimprich,Yoichi Taya,Katsuyuki Tamai,Kazuyasu Sakaguchi,Ettore Appella,Michael B. Kastan,Janet D. Siliciano +8 more
TL;DR: The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents, such as ionizing radiation, but not ultraviolet radiation as discussed by the authors.
Journal ArticleDOI
Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry
Donald F. Hunt,Robert A. Henderson,Jeffrey Shabanowitz,Kazuyasu Sakaguchi,Hanspeter Michel,Noelle Sevilir,Andrea L. Cox,Ettore Appella,Victor H. Engelhard +8 more
TL;DR: Microcapillary high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was used to fractionate and sequence subpicomolar amounts of peptides isolated from the MHC molecule HLA-A2.1.
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DNA damage activates p53 through a phosphorylation–acetylation cascade
Kazuyasu Sakaguchi,Julio E. Herrera,Shin'ichi Saito,Toru Miki,Michael Bustin,Alex Vassilev,Carl W. Anderson,Ettore Appella +7 more
TL;DR: It is suggested that DNA damage enhances p53 activity as a transcription factor in part through carboxy-terminal acetylation that, in turn, is directed by amino- terminal phosphorylation.
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Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.
Yutaka Kawakami,Siona Eliyahu,Cynthia H. Delgado,Paul F. Robbins,Kazuyasu Sakaguchi,Ettore Appella,John R. Yannelli,G J Adema,Toru Miki,Steven A. Rosenberg +9 more
TL;DR: Since the administration of TIL1200 plus interleukin 2 resulted in regression of metastatic cancer in the autologous patient, gp100 is a possible tumor rejection antigen and may be useful for the development of immunotherapies for patients with melanoma.
Journal ArticleDOI
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.
Yutaka Kawakami,Siona Eliyahu,Kazuyasu Sakaguchi,Paul F. Robbins,Licia Rivoltini,John R. Yannelli,Ettore Appella,Steven A. Rosenberg +7 more
TL;DR: One of the 9-mer peptides, AAGIGILTV, was most effective in sensitizing the T2 cells for TIL lysis and appears to be a very common immunogenic epitope for HLA-A2-restricted melanoma-specific TIL and may be useful for the development of immunotherapeutic strategies.