Ke Chen

TL;DR: An active anti-HIV principle, acacetin-7-O-beta-D-galactopyranoside, has been isolated from Chrysanthemum morifolium and a known flavone, chrysin, was found to be the most promising compound in this series of flavonoids.

TL;DR: The anti-HIV data indicated that the relative position and types of substituents on the phenolic hydroxy groups of either the natural lignans or the synthetic biphenyl compounds rather than the numbers of bromine(s) on the aromatic rings are of primary importance.

TL;DR: Two new lignans, interiotherins A and B and B, along with two known lignan, angeloylgomisin R and schisantherin D, were isolated from Kadsura interior and their structures and stereochemistries were determined from spectral data.

TL;DR: A review of the development of tubulin inhibitors can be found in this article, where the authors describe the recent progress being made in the discovery of novel antimitotic antitumor tubulin inhibitor.

TL;DR: A good correlation was found between cytotoxicity and inhibition of tubulin polymerization in the 2-phenyl-1,8-naphthyridin-4-one series and further investigation is underway to determine if substitution at the 3'-position and multisubstitutions in ring C will result in compounds with increased activity.