R
Robert E. Kilkuskie
Researcher at Hybridon, Inc
Publications - 38
Citations - 1767
Robert E. Kilkuskie is an academic researcher from Hybridon, Inc. The author has contributed to research in topics: DNA & Oligonucleotide. The author has an hindex of 20, co-authored 38 publications receiving 1698 citations. Previous affiliations of Robert E. Kilkuskie include University of North Carolina at Chapel Hill & University of Virginia.
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Journal ArticleDOI
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
Toshihiro Fujioka,Yoshiki Kashiwada,Robert E. Kilkuskie,L. M. Cosentino,Lawrence M. Ballas,Jack B. Jiang,William P. Janzen,Ih-Sheng Chen,Kuo Hsiung Lee +8 more
TL;DR: Evaluation of anti-HIV activity with eight derivatives of 1 revealed that dihydrobetulinic acid was also a potent inhibitor of HIV replication, and there was no apparent correlation between anti-hIV activity and the inhibition of PKC among these compounds.
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Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
Genichiro Nonaka,Itsuo Nishioka,Makoto Nishizawa,Takashi Yamagishi,Yoshiki Kashiwada,Ginger E. Dutschman,Anne J. Bodner,Robert E. Kilkuskie,Yung-Chi Cheng,Kuo Hsiung Lee +9 more
TL;DR: The mechanism by which tannins inhibit HIV may not be associated with this enzyme, and despite of their anti-RT activity, they appear to inhibit virus-cell interactions.
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Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.
TL;DR: An active anti-HIV principle, acacetin-7-O-beta-D-galactopyranoside, has been isolated from Chrysanthemum morifolium and a known flavone, chrysin, was found to be the most promising compound in this series of flavonoids.
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Anti-AIDS agents, 1. Isolation and characterization of four new tetragalloylquinic acids as a new class of HIV reverse transcriptase inhibitors from tannic acid.
Makoto Nishizawa,Takashi Yamagishi,Ginger E. Dutschman,William B. Parker,Anne J. Bodner,Robert E. Kilkuskie,Yung-Chi Cheng,Kuo Hsiung Lee +7 more
TL;DR: The inhibitory effect of 3 against DNA polymerases indicates that the selective antiviral action of 3 is determined by more than its action with HIV RT, and is comparable to their effects against the HIV RT at 30 microM and 10 microM, respectively.