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Kedchin Jearawuttanakul
Researcher at Mahidol University
Publications - 9
Citations - 183
Kedchin Jearawuttanakul is an academic researcher from Mahidol University. The author has contributed to research in topics: Chemistry & Knoevenagel condensation. The author has an hindex of 2, co-authored 6 publications receiving 39 citations.
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Journal ArticleDOI
High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents.
Phongthon Kanjanasirirat,Ampa Suksatu,Suwimon Manopwisedjaroen,Bamroong Munyoo,Patoomratana Tuchinda,Kedchin Jearawuttanakul,Sawinee Seemakhan,Sitthivut Charoensutthivarakul,Patompon Wongtrakoongate,Noppawan Rangkasenee,Supaporn Pitiporn,Neti Waranuch,Napason Chabang,Phisit Khemawoot,Khanit Sa-ngiamsuntorn,Yongyut Pewkliang,Piyanoot Thongsri,Somchai Chutipongtanate,Suradej Hongeng,Suparerk Borwornpinyo,Arunee Thitithanyanont +20 more
TL;DR: It is demonstrated, for the first time, that panduratin A exerts the inhibitory effect against SARS-CoV-2 infection at both pre-entry and post-infection phases.
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Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.
Khanit Sa-ngiamsuntorn,Ampa Suksatu,Yongyut Pewkliang,Piyanoot Thongsri,Phongthon Kanjanasirirat,Suwimon Manopwisedjaroen,Sitthivut Charoensutthivarakul,Patompon Wongtrakoongate,Supaporn Pitiporn,Jarinya Chaopreecha,Supasek Kongsomros,Kedchin Jearawuttanakul,Warawuth Wannalo,Phisit Khemawoot,Somchai Chutipongtanate,Suparerk Borwornpinyo,Arunee Thitithanyanont,Suradej Hongeng +17 more
TL;DR: Wang et al. as discussed by the authors optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model of human lung epithelial cells, Calu-3, to determine the anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component, andrographolide.
Journal ArticleDOI
Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with Remdesivir.
Supasek Kongsomros,Ampa Suksatu,Phongthon Kanjanasirirat,Suwimon Manopwisedjaroen,Somsak Prasongtanakij,Kedchin Jearawuttanakul,Suparerk Borwornpinyo,Suradej Hongeng,Arunee Thitithanyanont,Somchai Chutipongtanate +9 more
TL;DR: In this paper, small molecule inhibitors of extracellular vesicles (EVs) could exert an anti-SARS-CoV-2 effect with no apparent cytotoxicity.
Journal ArticleDOI
Cleistanthin A induces apoptosis and suppresses motility of colorectal cancer cells.
Kedchin Jearawuttanakul,Phattharachanok Khumkhrong,Kanoknetr Suksen,Somrudee Reabroi,Bamroong Munyoo,Patoomratana Tuchinda,Suparerk Borwornpinyo,Nittaya Boonmuen,Arthit Chairoungdua +8 more
TL;DR: Investigation of the molecular mechanisms that underpin the anticancer effects of cleistanthin A in two CRC cell lines suggest that CA has the potential to develop as an effective and novel therapeutic drug for CRC patients.
Journal ArticleDOI
Copper-catalyzed synthesis and anticancer activity evaluation of indolo[1,2-a]quinoline derivatives
Adisak Thanetchaiyakup,Suparerk Borwornpinyo,Hassayaporn Rattanarat,Phongthon Kanjanasirirat,Kedchin Jearawuttanakul,Sawinee Seemakhan,Nutthawat Chuanopparat,Paiboon Ngernmeesri +7 more
TL;DR: A simple and effective one-pot synthesis of substituted indolo[1,2-a]quinolines has been developed and some of the synthesized compounds were found to be active against human breast and colorectal cancer cells with IC50 values in the range of 6.21–46.91 μM.