K
Khanit Sa-ngiamsuntorn
Researcher at Mahidol University
Publications - 27
Citations - 448
Khanit Sa-ngiamsuntorn is an academic researcher from Mahidol University. The author has contributed to research in topics: Mesenchymal stem cell & Medicine. The author has an hindex of 9, co-authored 21 publications receiving 206 citations.
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Journal ArticleDOI
High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents.
Phongthon Kanjanasirirat,Ampa Suksatu,Suwimon Manopwisedjaroen,Bamroong Munyoo,Patoomratana Tuchinda,Kedchin Jearawuttanakul,Sawinee Seemakhan,Sitthivut Charoensutthivarakul,Patompon Wongtrakoongate,Noppawan Rangkasenee,Supaporn Pitiporn,Neti Waranuch,Napason Chabang,Phisit Khemawoot,Khanit Sa-ngiamsuntorn,Yongyut Pewkliang,Piyanoot Thongsri,Somchai Chutipongtanate,Suradej Hongeng,Suparerk Borwornpinyo,Arunee Thitithanyanont +20 more
TL;DR: It is demonstrated, for the first time, that panduratin A exerts the inhibitory effect against SARS-CoV-2 infection at both pre-entry and post-infection phases.
Journal ArticleDOI
Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.
Khanit Sa-ngiamsuntorn,Ampa Suksatu,Yongyut Pewkliang,Piyanoot Thongsri,Phongthon Kanjanasirirat,Suwimon Manopwisedjaroen,Sitthivut Charoensutthivarakul,Patompon Wongtrakoongate,Supaporn Pitiporn,Jarinya Chaopreecha,Supasek Kongsomros,Kedchin Jearawuttanakul,Warawuth Wannalo,Phisit Khemawoot,Somchai Chutipongtanate,Suparerk Borwornpinyo,Arunee Thitithanyanont,Suradej Hongeng +17 more
TL;DR: Wang et al. as discussed by the authors optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model of human lung epithelial cells, Calu-3, to determine the anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component, andrographolide.
Posted ContentDOI
Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component Andrographolide in human lung epithelial cells and cytotoxicity evaluation in major organ cell representatives
Khanit Sa-ngiamsuntorn,Ampa Suksatu,Yongyut Pewkliang,Piyanoot Thongsri,Phongthon Kanjanasirirat,Suwimon Manopwisedjaroen,Sitthivut Charoensutthivarakul,Patompon Wongtrakoongate,Supaporn Pitiporn,Phisit Khemawoot,Somchai Chutipongtanate,Suparerk Borwornpinyo,Arunee Thitithanyanont,Suradej Hongeng +13 more
TL;DR: Experimental evidence is provided in favor of A. paniculata and andrographolide for further development as a monotherapy or in combination with other effective drugs against SARS-CoV–2 infection.
Journal ArticleDOI
Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers
Khanit Sa-ngiamsuntorn,Adisak Wongkajornsilp,Kanda Kasetsinsombat,Sunisa Duangsa-ard,Lalana Nuntakarn,Suparerk Borwornpinyo,Pravit Akarasereenont,S. Limsrichamrern,Suradej Hongeng +8 more
TL;DR: The hepatocyte-like cells had polygonal morphology and steadily produced albumin, glycogen, urea and UGT1A1 beyond 6 months while maintaining proliferative capacity and could serve as a sensitive model for profiling xenobiotic-induced expression of CYP450.
Journal ArticleDOI
A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax.
Yongyut Pewkliang,Siriwan Rungin,Kaewta Lerdpanyangam,Apisak Duangmanee,Phongthon Kanjanasirirat,Phichaya Suthivanich,Khanit Sa-ngiamsuntorn,Suparerk Borwornpinyo,Jetsumon Sattabongkot,Rapatbhorn Patrapuvich,Suradej Hongeng +10 more
TL;DR: imHCs, which maintain a hepatocyte phenotype and drug-metabolizing enzyme expression, constitute an alternative host for in vitro Plasmodium liver-stage studies, particularly those addressing the biology of P. vivax hypnozoite, and potentially offer a novel, robust model for screening drugs against liver- stage parasites.