Keiichi Tabata

TL;DR: Upon evaluation of 17 compounds, 1-14 and 16-18, and compound 15, semi-synthesized from 14 by acetylation, for their inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, all of the compounds exhibited marked anti-inflammatory activity with a 50% inhibitory dose (ID(50) of 0.05-0.49 mg/ear.

TL;DR: Results suggest that isobavachalcone induces apoptotic cell death in neuroblastoma via the mitochondrial pathway and has no cytotoxicity against normal cells, and may be applicable as an efficacious and safe drug for the treatment of Neuroblastoma.

TL;DR: Results suggest that xanthoangelol induces apoptotic cell death by activatation of caspase-3 in neuroblastoma and leukemia cells through a mechanism that does not involve Bax/Bcl-2 signal transduction, and may be applicable as an effective drug for treatment of neuroblastomas and leukemia.

TL;DR: Limonoids isolated from Azadirachta indica seed extracts exhibited potent cytotoxic activity against HL60 leukemia cells with IC(50) values in the range 2.7-3.1 μM, suggesting that compounds 7, 18, and 28 induced apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways.

TL;DR: Poricotriol A induced typical apoptotic cell death in HL60 and A549 cells on evaluation of the apoptosis-inducing activity by flow cytometric analysis, and was shown to possess high selective toxicity in lung cancer cells since it exhibited only weak cytotoxicity against a normal lung cell line (WI-38).