https://chemistry.mdma.ch/hiveboard/rhodium/pdf/archive/merbst/quinoline1999.pdf

Quinoline, quinazoline and acridone alkaloids

Asymmetric 1,3-Dipolar Cycloaddition Reactions

The Diels-Alder reaction has both enabled and shaped the art and science of total synthesis over the last few decades to an extent which, arguably, has yet to be eclipsed by any other transformation in the current synthetic repertoire. With myriad applications of this magnificent pericyclic reaction, often as a crucial element in elegant and programmed cascade sequences facilitating complex molecule construction, the Diels-Alder cycloaddition has afforded numerous and unparalleled solutions to a diverse range of synthetic puzzles provided by nature in the form of natural products. In celebration of the 100th anniversary of Alder's birth, selected examples of the awesome power of the reaction he helped to discover are discussed in this review in the context of total synthesis to illustrate its overall versatility and underscore its vast potential which has yet to be fully realized.

https://www.ch.ic.ac.uk/local/organic/pericyclic/DA.pdf

The Diels--Alder reaction in total synthesis.

Introduction Cationic domino reactions Anionic domino reactions Radical domino reactions Pericyclic domino reactions Photochemically induced domino processes Transition metal catalysis Domino reactions initiated by oxidation or reduction Enzymes in domino reactions Multicomponent reactions Special techniques in domino reactions

Domino Reactions in Organic Synthesis

Asymmetric fluorination, trifluoromethylation, and perfluoroalkylation reactions.

(+)-19-Nordeoxycorticosterone (1) has been synthesised by A-ring construction of the (+)-A-nor-B-trienic steroid (2) obtained enantioselectively from the alkenic benzocyclobutene (12).

A facile and enantioselective total synthesis of (+)-19-nordeoxycorticosterone

Stereoselective synthesis of (±)-cedranediol via intramolecular double michael reaction

A convenient and practical route for enantioselective synthesis of the A-nor-B-trienic steroid 2via an intramolecular [4 + 2] cycloaddition of the olefinic ortho-quinodimethane 3 generated in situ by thermolysis of the olefinic benzocyclobutene 4 is reported. This leads to the total synthesis of (+)-11-deoxy-19-norcorticosterone 1 by use of a usual chemical manipulation on intermediate 2.

A practical route for enantioselective total synthesis of (+)-11-deoxy-19-norcorticosterone via intramolecular Diels–Alder addition to an ortho-quinodimethane

Simple design for the construction of complex gibberellin framework—Stereoselective synthesis of a possible key intermediate to GA12 via Pd2+-promoted cycloalkenylation reaction

Keiichiro Fukumoto

Papers

A facile and enantioselective total synthesis of (+)-19-nordeoxycorticosterone

Stereoselective synthesis of (±)-cedranediol via intramolecular double michael reaction

A practical route for enantioselective total synthesis of (+)-11-deoxy-19-norcorticosterone via intramolecular Diels–Alder addition to an ortho-quinodimethane

Simple design for the construction of complex gibberellin framework—Stereoselective synthesis of a possible key intermediate to GA12 via Pd2+-promoted cycloalkenylation reaction

A convenient access to 3,4-disubstituted isoquinolines from benzocyclobutenyl ketoximes