Keiko Tano

TL;DR: It is suggested that MALAT‐1 is a novel class of non‐coding RNA that promotes cell motility through transcriptional and post‐transcriptional regulation of motility related gene expression.

TL;DR: This study determined the half-lives of 11,052 mRNAs and 1418 ncRNAs in HeLa Tet-off (TO) cells by developing a novel genome-wide method, which was named 5'-bromo-uridine immunoprecipitation chase-deep sequencing analysis (BRIC-seq), and identified and characterized several novel long nCRNAs involved in cell proliferation from the group of short-lived nc RNAs.

TL;DR: A review of recent findings regarding the roles of lncRNAs in cancer biology highlights the importance of knowing the underlying molecular mechanisms by which these molecules regulate cancer development.

TL;DR: It is suggested that RNPS1, SRm160, and IBP160 contribute to the localization of MALat-1 to nuclear speckles, where MALAT-1 could be involved in regulating gene expression.

TL;DR: The results suggest that distinct sets of nuclear long ncRNAs play roles in cellular defense mechanisms against specific genotoxic agents, and that particular long nCRNAs have the potential to be surrogate indicators of a specific cell stress.