Keishi Narita

TL;DR: A role for Rab7 and Rab9 in the Golgi targeting of glycosphingolipids is demonstrated and a new therapeutic approach for restoring normal lipid trafficking in NP-C cells is suggested.

TL;DR: 20 FPP synthases, each of which has a different amino acid at position 81, are constructed and analyzed, and observations strongly indicate that the amino acid does not come into contact with the substrates but directly contacts the ω-terminal of an elongating allylic product.

TL;DR: It is reported that HSulf-1 expression in MDA-MB-468 breast carcinoma clonal lines leads to reduced proliferation in vitro and reduced tumor burden in athymic nude mice in vivo and provides the first evidence of a novel mechanism by which HS sulfur-1 modulates the function of heparan sulfate binding VEGF165 in proliferation and angiogenesis.

TL;DR: Using a genetically encoded calcium indicator targeted to primary cilia, calcium signaling in cilia of mouse fibroblasts and kidney cells upon chemical or mechanical stimulation is visualized with high specificity, high sensitivity and wide dynamic range.

TL;DR: Data indicate that HSulf-1 is epigenetically silenced in ovarian cancer and that epigenetic therapy targeting HS sulfur-1 might sensitize ovarian tumors to conventional first-line therapies.