Keith L. Shelton

TL;DR: Depression and stress are two states during cocaine abstinence which users identify as precipitating relapse, and JDTic may have properties which attenuate both.

TL;DR: It is found that the packing density of astrocytes that were expressing glial fibrillary acidic protein increased in the nucleus accumbens core (NAcore) during abstinence from EtOH self-administration, demonstrating that NAcore astroCytes can shape the motivation to self-administer ethanol.

TL;DR: It is found that a histone deacetylase inhibitor, trichostatin A, caused an increase in 2-bottle ethanol intake, which implicate specific brain regional gene networks as potentially important mechanisms underlying individual variation in ethanol intake.

TL;DR: A simple and reliable behavioral model to study EDE in inbred C57BL/6NCrl mice is established and could greatly facilitate further studies on molecular mechanisms of ethanol craving behavior.

TL;DR: AV411 has properties consistent with the ability to attenuate relapse precipitated by stress and methamphetamine "slips" during abstinence, and reinforces interest in atypical neurobiological mechanisms which could be exploited for developing novel medications for treating drug abuse disorders.