Showing papers in "European Journal of Pharmacology in 2010"

TL;DR: Depressed patients also show impairments of executive functions and their recent exploration through brain imaging techniques has recently permitted to formulate some general hypotheses on the possible involvement of different brain areas in MD.

TL;DR: Results indicate that chlorogenic acid may exert anti-amnesic activity via inhibition of acetylcholinesterase and malondialdehyde in the hippocampus and frontal cortex in a dose-dependent manner.

TL;DR: Results suggest that crocin and crocetin provide neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.

TL;DR: The results demonstrate that quercetin suppressed the viability of HeLa cells in a dose-dependent manner by inducing G2/M phase cell cycle arrest and mitochondrial apoptosis through a p53-dependent mechanism.

TL;DR: New data indicate that in diabetic rats, resveratrol is able to reduce hyperglycemia and point to the potential possibility of use of resver atrol in preventing and/or treating both obesity and diabetes.

TL;DR: Recent studies with genetically modified mice have shown that NR1 NMDA receptor subunit deletion, specifically from the granule cells of the dentate gyrus, not only impairs short-term spatial memory but also reduces anxiety, which suggests that NMDA receptors in ventral hippocampus may be a key locus supporting the anxiolytic effects ofNMDA receptor antagonists.

TL;DR: It is demonstrated that FX reduces the levels of pro-inflammatory mediators including NO, PGE₂, IL-1β, TNF-α, and IL-6 via the inhibition of NF-κB activation and the suppression of MAPK phosphorylation in RAW 264.7 cells.

TL;DR: The release of various pro-inflammatory factors, the production of reactive oxygen species, and the activation of signal pathways leading to neuroinflammation were discussed in relation to microglial activation, and microglia are an important target for anti-inflammatory activities of resveratrol in the brain.

TL;DR: The evidence on the common molecular pathways between depression and Alzheimer's disease is examined and these pathways are discussed as new pharmacological targets for the treatment of both major depression and Alzheimers disease.

TL;DR: In vitro and in vivo results suggested that activation of the PI3K/Akt pathway and the inhibition of NF-kappaB were involved in the protective effects of icariin on LPS-induced acute inflammatory responses.

TL;DR: It is suggested that melatonin has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.

TL;DR: Results clearly demonstrate that Liraglutide and other GLP-1 analogues elicit effects on neurotransmission in the brain and are not only effective inmodulating insulin-release and achieving glycaemic control in type 2 diabetes, but are also effective in modulating synaptic plasticity.

TL;DR: It is concluded that resveratrol diet represents a novel approach to the treatment of chronic intestinal inflammation and significantly attenuated the clinical signs such as loss of body weight, diarrhea and rectal bleeding.

TL;DR: Data suggest that suppression of ADAM17 and downregulation of PI3K/Akt and Ras/MAPK signaling pathways may contribute to gallic acid-induced decrease of invasiveness and may be a valuable candidate for treatment of brain tumor.

TL;DR: The results suggest that the guanylate cyclase C agonist linaclotide elicits potent pharmacological responses locally in the gastrointestinal tract, and that orally administered guanylation C agonists may be capable of improving bowel habits in patients suffering from irritable bowel syndrome with constipation and chronic constipation.

TL;DR: The present work shows, through several independent experiments, that palonosetron uniquely triggers 5-HT(3) receptor internalization and induces prolonged inhibition of receptor function.

TL;DR: Berberine inhibits the proliferation of MCF-7 breast cancer cells through a mitochondria and caspase dependent apoptotic pathway and it is possible that berberine may serve as a potential naturally occurring compound for breast cancer therapy.

TL;DR: It is demonstrated that chrysin acts as a hepatoprotective and antioxidant agent against d-galactosamine-induced hepatotoxicity and reduces glutathione, vitamin C and vitamin E.

TL;DR: The present article reviews the effects of reactive oxygen species on endothelial function in diabetes and addresses possible therapeutic interventions.

TL;DR: Findings suggested that the inhibition on MMP-7 expression by andrographolide may be through suppression on PI3K/Akt/AP-1 signaling pathway, which in turn led to the reduced invasiveness of the cancer cells.

TL;DR: In this paper, the group II metabotropic glutamate receptors (mGlu(2/3) receptors) were shown to presynaptically control glutamate and dopamine release throughout the mesocorticolimbic structures involved in reward processing and drug seeking.

TL;DR: Nine naturally occurring compounds isolated from Citrus jambhiri Lush and Citrus pyriformis Hassk could be considered as good candidates for the development of novel P-gp/MDR1 reversal agents which may enhance the accumulation and efficacy of chemotherapy agents.

TL;DR: The results indicate that scopoletin's antidepressant-like effect is dependent on the serotonergic (5-HT(2A) receptors), noradrenergic (alpha(1)- and alpha(2)-adrenoceptors) and dopaminergic (dopamine D(1) and D(2) receptors) systems.

TL;DR: Results indicate that ginsenoside Rg3 inhibits NF-kappaB, and enhances the susceptibility of prostate cancer cells to docetaxel and other chemotherapeutics, which could be useful as an anti-cancer agent.

TL;DR: The data suggest that CAPE inhibits TNF-alpha-dependent NFkappaB activation via direct inhibition of IKK as well as activation of Nrf2 pathway, in which the functional groups in CAPE may be involved.

TL;DR: Adjusted formula for QTc(n)-B is suitable forQT correction in rats but its use should be considered carefully in case of very low heart rate.

TL;DR: Considering the contribution of TRpV1 to the development of inflammation in the gastrointestinal tract, the potential side effects of TRPV1 agonist cannot be neglected while in seeking and developing the novel TRPv1 agonists.

TL;DR: An overview of selected aspects of neurocognition in bipolar disorder with a focus on the relative contributions of medications as well as medical and psychiatric comorbid conditions to cognitive dysfunction is provided.

TL;DR: Modifications in the HPA-axis and the serotonergic system may contribute to the development of cognitive decline and eventually AD, with patients suffering from lifetime depression having a twofold higher chance of developing AD and exhibiting more AD-related neuropathology.

TL;DR: The bilateral pain reduction after unilateral toxin application and the effectiveness of lower dose with the faster onset after the intrathecal injection suggest the involvement of the central nervous system in the antinociceptive action of BTX-A in painful diabetic neuropathy.