Kellie S. Gross

TL;DR: It is found that systemic administration of mGluR subtype-specific positive allosteric modulators had opposite effects on dendritic spine densities, and this data provides insight on the ability of group I mGLURs to induce structural plasticity in the NAc and demonstrates that the group ImGluRs are capable of producing not just distinct, but opposing, effects ondendrite spine density.

TL;DR: Though the primary focus is on data collected in females, effects of oestradiol on memory in males will be discussed, as will sex differences in the molecular mechanisms that regulate oestrogenic modulation of memory, which may have important implications for the development of future cognitive therapies.

TL;DR: It is suggested that mGluR5 activation is necessary for estradiol-mediated enhancement of responses to cocaine, but that direct mGLUR5activation is insufficient to mimic the female response to estradio.

TL;DR: This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.

TL;DR: Examination of the role of actin polymerization and c-Jun N-terminal kinase (JNK) phosphorylation in mediating effects of dorsal hippocampally infused G-1 on CA1 dendritic spine density and consolidation of object recognition and spatial memories in ovariectomized mice demonstrated that GPER-mediated hippocampal spinogenesis and memory consolidation depend on JNK and cofilin signaling.