K
Kelly J. Gordon
Researcher at Duke University
Publications - 8
Citations - 1175
Kelly J. Gordon is an academic researcher from Duke University. The author has contributed to research in topics: Signal transduction & Alternating hemiplegia of childhood. The author has an hindex of 7, co-authored 8 publications receiving 1080 citations.
Papers
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Journal ArticleDOI
Role of transforming growth factor-β superfamily signaling pathways in human disease
Kelly J. Gordon,Gerard C. Blobe +1 more
TL;DR: Ongoing studies will enable targeting of TGF-beta superfamily signaling pathways for the chemoprevention and treatment of human disease.
Journal ArticleDOI
The type III TGF-β receptor suppresses breast cancer progression
Mei Dong,Tam How,Kellye C. Kirkbride,Kelly J. Gordon,Jason D. Lee,Nadine Hempel,Patrick J. Kelly,Benjamin J. Moeller,Jeffrey R. Marks,Gerard C. Blobe +9 more
TL;DR: Restoring TβRIIIexpression inbreastcancercellsdramaticallyinhibited� tumorinvasivenessinvitroandtumorinvasion,�angiogenesis,�andmetastasisinvivo during humanbreast cancer development that increasesmetastaticpotential.
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Loss of type III transforming growth factor β receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression
TL;DR: A role for loss of TbetaRIII expression during the EMT of pancreatic cancer progression is supported, with a specific role for sT betaRIII in suppressing EMT-associated increases in motility and invasion.
Journal ArticleDOI
Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.
TL;DR: The data suggest that BMP signaling, through Smad1 induction and upregulation of MMP-2, is an important mediator of pancreatic cancer invasiveness and a potential therapeutic target for treating this deadly disease.
Journal ArticleDOI
Motor function domains in alternating hemiplegia of childhood.
Melanie Masoud,Kelly J. Gordon,Amanda Hall,Joan Jasien,Kara L. Lardinois,Julie Uchitel,Melissa McLean,Lyndsey Prange,Jeffrey Wuchich,Mohamad A. Mikati +9 more
TL;DR: To characterize motor function profiles in alternating hemiplegia of childhood, and to investigate interrelationships between these domains and with age.