K
Kelly P Brock
Researcher at Harvard University
Publications - 33
Citations - 1239
Kelly P Brock is an academic researcher from Harvard University. The author has contributed to research in topics: Protein structure & Chemistry. The author has an hindex of 11, co-authored 29 publications receiving 608 citations. Previous affiliations of Kelly P Brock include Massachusetts Institute of Technology.
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Journal ArticleDOI
The EVcouplings Python framework for coevolutionary sequence analysis
Thomas A. Hopf,Anna G. Green,Benjamin Schubert,Sophia Mersmann,Charlotta P I Schärfe,Charlotta P I Schärfe,John Ingraham,Agnes Toth-Petroczy,Kelly P Brock,Adam J. Riesselman,Perry Palmedo,Perry Palmedo,Chan Kang,Robert L. Sheridan,Eli J. Draizen,Christian Dallago,Christian Dallago,Chris Sander,Debora S. Marks +18 more
TL;DR: The EVcouplings framework is presented, a fully integrated open-source application and Python package for coevolutionary analysis that enables generation of sequence alignments, calculation and evaluation of evolutionary couplings, and de novo prediction of structure and mutation effects.
Journal ArticleDOI
Disease variant prediction with deep generative models of evolutionary data.
Jonathan Frazer,Pascal Notin,Mafalda Dias,Aidan N. Gomez,Joseph K. Min,Kelly P Brock,Yarin Gal,Debora S. Marks,Debora S. Marks +8 more
TL;DR: This paper proposed an approach that leverages deep generative models to predict variant pathogenicity without relying on labels, by modeling the distribution of sequence variation across organisms, implicitly capturing constraints on the protein sequences that maintain fitness.
Journal ArticleDOI
Cryo-electron microscopy structure of the lipid droplet-formation protein seipin
Xuewu Sui,Henning Arlt,Kelly P Brock,Zon Weng Lai,Frank DiMaio,Debora S. Marks,Maofu Liao,Robert V. Farese,Robert V. Farese,Tobias C. Walther +9 more
TL;DR: A structure and functional testing suggest a model in which seipin oligomers initially detect forming LDs in the ER via HHs and subsequently act as membrane anchors to enable lipid transfer and LD growth.
Journal ArticleDOI
Inferring protein 3D structure from deep mutation scans.
Nathan J Rollins,Kelly P Brock,Frank J. Poelwijk,Michael A Stiffler,Nicholas P. Gauthier,Chris Sander,Chris Sander,Debora S. Marks,Debora S. Marks +8 more
TL;DR: It is found that the strongest epistatic pairings from genetic screens of three proteins, a ribozyme and a protein interaction reveal 3D contacts within and between macromolecules, suggesting that genomics-based techniques can efficiently predict 3D structure.
Journal ArticleDOI
Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis
Megan Sjodt,Kelly P Brock,Genevieve S Dobihal,Patricia D. A. Rohs,Anna G. Green,Thomas A. Hopf,Alexander J. Meeske,Veerasak Srisuknimit,Daniel Kahne,Suzanne Walker,Debora S. Marks,Thomas G. Bernhardt,David Z. Rudner,Andrew C. Kruse +13 more
TL;DR: The crystal structure of Thermus thermophilus RodA is reported, determined using evolutionary covariance-based fold prediction to enable molecular replacement and provides a framework for understanding bacterial cell wall synthesis and SEDS protein function.