K
Kelly R. Bales
Researcher at Pfizer
Publications - 149
Citations - 21323
Kelly R. Bales is an academic researcher from Pfizer. The author has contributed to research in topics: Amyloid precursor protein & Apolipoprotein E. The author has an hindex of 68, co-authored 147 publications receiving 20112 citations. Previous affiliations of Kelly R. Bales include Eli Lilly and Company & Washington University in St. Louis.
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Journal ArticleDOI
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
Ronald Demattos,Kelly R. Bales,David J. Cummins,Jean-Cosme Dodart,Steven M. Paul,David M. Holtzman +5 more
TL;DR: Although peripheral administration of m266 to PDAPP mice markedly reduces Aβ deposition, m266 did not bind to Aβ deposits in the brain, and m266 appears to reduce brain Aβ burden by altering CNS and plasma Aβ clearance.
Journal ArticleDOI
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
John R. Cirrito,Kelvin A. Yamada,Mary Beth Finn,Robert S. Sloviter,Kelly R. Bales,Patrick C. May,Darryle D. Schoepp,Steven M. Paul,Steven Mennerick,David M. Holtzman +9 more
TL;DR: It is demonstrated that Aβ levels in the brain interstitial fluid are dynamically and directly influenced by synaptic activity on a timescale of minutes to hours, and it is suggested that synaptic activity may modulate a neurodegenerative disease process, in this case by influencing Aβ metabolism and ultimately region-specific Aβ deposition.
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Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Joseph M. Castellano,Jungsu Kim,Floy R. Stewart,Hong Jiang,Ronald B. DeMattos,Bruce W. Patterson,Anne M. Fagan,John C. Morris,Kwasi G. Mawuenyega,Carlos Cruchaga,Alison Goate,Kelly R. Bales,Steven M. Paul,Randall J. Bateman,David M. Holtzman +14 more
TL;DR: New light is shed on how apoE4 is implicated in AD and the Aβ clearance pathway is highlighted as a new target for developing drugs to slow or even halt the accumulation of amyloid plaques in patients with AD.
Journal ArticleDOI
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
Jean Cosme Dodart,Kelly R. Bales,Kimberley S. Gannon,Stephen J. Greene,Ronald Demattos,Chantal Mathis,Cynthia DeLong,Su Wu,Xin Wu,David M. Holtzman,Steven M. Paul +10 more
TL;DR: This article showed that passive immunization with this anti-Aβ monoclonal antibody can very rapidly reverse memory impairment in certain learning and memory tasks in the PDAPP mouse model of AD, owing perhaps to enhanced peripheral clearance and sequestration of a soluble brain Aβ species.
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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
David M. Holtzman,Kelly R. Bales,Tanya Tenkova,Anne M. Fagan,Maia Parsadanian,Leah J. Sartorius,Brian Mackey,John W. Olney,Daniel W. McKeel,David F. Wozniak,Steven M. Paul +10 more
TL;DR: The data demonstrate a critical and isoform-specific role for apoE in neuritic plaque formation, a pathological hallmark of AD.