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Ken A. Dill
Researcher at Stony Brook University
Publications - 414
Citations - 44350
Ken A. Dill is an academic researcher from Stony Brook University. The author has contributed to research in topics: Protein folding & Solvation. The author has an hindex of 99, co-authored 401 publications receiving 41289 citations. Previous affiliations of Ken A. Dill include Chiron Corporation & State University of New York System.
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Dominant forces in protein folding
TL;DR: The present review aims to provide a reassessment of the factors important for folding in light of current knowledge, including contributions to the free energy of folding arising from electrostatics, hydrogen-bonding and van der Waals interactions, intrinsic propensities, and hydrophobic interactions.
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From Levinthal to pathways to funnels
Ken A. Dill,Hue Sun Chan +1 more
TL;DR: The general energy landscape picture provides a conceptual framework for understanding both two-state and multi-state folding kinetics and hopes to learn much more about the real shapes of protein folding landscapes.
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Principles of protein folding--a perspective from simple exact models.
Ken A. Dill,Sarina Bromberg,Kaizhi Yue,Klaus M. Fiebig,David P. Yee,Paul Thomas,Hue Sun Chan +6 more
TL;DR: These studies suggest the possibility of creating “foldable” chain molecules other than proteins, and can account for the properties that characterize protein folding: two‐state cooperativity, secondary and tertiary structures, and multistage folding kinetics.
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The Protein-Folding Problem, 50 Years On
Ken A. Dill,Justin L. MacCallum +1 more
TL;DR: Progress is reviewed on three broad questions: What is the physical code by which an amino acid sequence dictates a protein’s native structure?
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Theory for the folding and stability of globular proteins.
TL;DR: Using lattice statistical mechanics, theory is developed to account for the folding of a heteropolymer molecule such as a protein to the globular and soluble state and the number of accessible conformations is calculated to be an exceedingly small fraction of the number available to the random coil.