Ken Murata

TL;DR: Investigating the possible coexpression of kisspeptin, neurokinin B (NKB), and dynorphin A (Dyn) in neurons of the ARC of the goat and evaluating their potential roles in generating GnRH pulses found that all three neuropeptides are coexpressed in the same population of neurons.

TL;DR: This study identifies an olfactory signal molecule that activates the central regulator of reproduction, the gonadotropin-releasing hormone (GnRH) pulse generator, in goats and electrophysiologically demonstrated that one of these compounds, 4-ethyloctanal, activates the GnRH pulse generator in female goats.

TL;DR: Using electrophysiological techniques to record multiple‐unit activity (MUA) in close proximity to kisspeptin neurones in the arcuate nucleus (ARC) of Shiba goats, it is found that bursts (volleys) of MUA occur at regular intervals, and repetitive bursts are invariably associated with discrete pulses of LH, suggesting that the ARC kisspe leptin neurones may be the intrinsic source of the GnRH pulse generator.

TL;DR: The results suggest that transmission of the pheromone signal to the ARC, represented by an instantaneous rise, activates the GnRH pulse generator.

TL;DR: It is demonstrated that a central infusion of NKB elicited a discharge of LH, which was associated with the activation of a large population of ARC kisspeptin/NKB neurons in seasonally anestrous ewes, which suggests that NKB plays a stimulatory role in the control of pulsatile GnRH secretion.