R
Robert A. Steiner
Researcher at University of Washington
Publications - 183
Citations - 23404
Robert A. Steiner is an academic researcher from University of Washington. The author has contributed to research in topics: Gonadotropin-releasing hormone & Hypothalamus. The author has an hindex of 71, co-authored 181 publications receiving 22298 citations. Previous affiliations of Robert A. Steiner include Oberlin College & University of Maryland, Baltimore.
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Journal ArticleDOI
A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse
Michelle L. Gottsch,Matthew Cunningham,Jeremy Troy Smith,Simina M. Popa,Blake V. Acohido,William F. Crowley,Stephanie B. Seminara,Donald K. Clifton,Robert A. Steiner +8 more
TL;DR: Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54, and it is concluded that kisspeptin-GPR54 signaling may be part of the hypothalamus circuitry that governs the hypothalamic secretion of GnRH.
Journal ArticleDOI
Leptin is a metabolic signal to the reproductive system
I A Barash,Clement C. Cheung,David S. Weigle,H Ren,E B Kabigting,Joseph L. Kuijper,Donald K. Clifton,Robert A. Steiner +7 more
TL;DR: It is demonstrated that leptin stimulates the reproductive endocrine system in both sexes of ob/ob mice and suggested that leptin may serve as a permissive signal to the reproductive system of normal animals.
Journal ArticleDOI
Regulation of Kiss1 gene expression in the brain of the female mouse.
TL;DR: Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion and whether estradiol regulates KiSS-1 in the forebrain of the female mouse is examined.
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Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Seong-Kyu Han,Michelle L. Gottsch,Kathy J Lee,Simina M. Popa,Jeremy Troy Smith,Sonya K Jakawich,Donald K. Clifton,Robert A. Steiner,Allan E. Herbison +8 more
TL;DR: It is demonstrated that kisspeptin exerts a potent depolarizing effect on the excitability of almost all adult GnRH neurons and that the responsiveness of Gn RH neurons tokisspeptin increases over postnatal development.
Journal ArticleDOI
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
Michael S. Irwig,Gregory S. Fraley,Jeremy Troy Smith,Blake V. Acohido,Simina M. Popa,Matthew Cunningham,Michelle L. Gottsch,Donald K. Clifton,Robert A. Steiner +8 more
TL;DR: These results demonstrate that GnRH neurons are direct targets for regulation by kisspeptins and that KiSS-1 mRNA is regulated by gonadal hormones, suggesting that Ki SS-1 neurons play an important role in the feedback regulation of gonadotropin secretion.